(Q53242629)

12 May 2018

title

Engineered biosynthesis of pimaricin derivatives with improved antifungal activity and reduced cytotoxicity. (English)

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12 May 2018

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Zhen Qi

1

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12 May 2018

Qianjin Kang

2

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12 May 2018

Chunyan Jiang

3

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12 May 2018

Mo Han

4

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12 May 2018

Linquan Bai

5

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12 May 2018

language of work or name

English

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publication date

8 May 2015

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12 May 2018

Applied Microbiology and Biotechnology

published in

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12 May 2018

volume

99

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12 May 2018

issue

16

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12 May 2018

page(s)

6745-6752

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12 May 2018

https://scigraph.springernature.com/pub.10.1007/s00253-015-6635-9

exact match

0 references

cites work

Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

21 January 2018

1 reference

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The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

Probing the structure-function relationship of polyene macrolides: engineered biosynthesis of soluble nystatin analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

Amphotericin biosynthesis in Streptomyces nodosus: deductions from analysis of polyketide synthase and late genes

21 January 2018

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Candida albicans drug resistance another way to cope with stress

21 January 2018

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Biosynthesis of amphotericin derivatives lacking exocyclic carboxyl groups

21 January 2018

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Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis

21 January 2018

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Engineered biosynthesis of disaccharide-modified polyene macrolides

21 January 2018

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Identification of a novel Streptomyces chattanoogensis L10 and enhancing its natamycin production by overexpressing positive regulator ScnRII.

21 January 2018

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Redesign of polyene macrolide glycosylation: engineered biosynthesis of 19-(O)-perosaminyl-amphoteronolide B.

21 January 2018

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Structure of Cytochrome P450 PimD Suggests Epoxidation of the Polyene Macrolide Pimaricin Occurs via a Hydroperoxoferric Intermediate

21 January 2018

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Structures of amphotericin B-cholesterol complex.

21 January 2018

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An amphotericin B-ergosterol covalent conjugate with powerful membrane permeabilizing activity.

21 January 2018

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Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.

21 January 2018

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The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.

21 January 2018

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Comparison of caspofungin and amphotericin B for invasive candidiasis

21 January 2018

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Analysis of the mycosamine biosynthesis and attachment genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455.

21 January 2018

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21 January 2018

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Two polyene amides produced by genetically modified Streptomyces diastaticus var. 108.

21 January 2018

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Versatility of enzymes catalyzing late steps in polyene 67-121C biosynthesis

21 January 2018

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Transcriptome-guided identification of SprA as a pleiotropic regulator in Streptomyces chattanoogensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-015-6635-9

10.1007/S00253-015-6635-9

21 January 2018

Identifiers

DOI

1 reference

12 May 2018

1 reference

12 May 2018