(Q53256531)

12 May 2018

title

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis. (English)

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12 May 2018

author name string

Frankie Chi Fat Ko

1

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12 May 2018

Lo-Kong Chan

2

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12 May 2018

Karen Man-Fong Sze

3

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12 May 2018

Yin-Shan Yeung

4

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12 May 2018

Edith Yuk-Ting Tse

5

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12 May 2018

Ping Lu

6

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12 May 2018

Ming-Hua Yu

7

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12 May 2018

Irene Oi-Lin Ng

8

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12 May 2018

Judy Wai Ping Yam

9

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12 May 2018

language of work or name

English

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publication date

1 January 2013

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12 May 2018

published in

Nature Communications

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12 May 2018

volume

4

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12 May 2018

page(s)

1618

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12 May 2018

Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity

21 January 2018

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Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver

21 January 2018

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The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells

21 January 2018

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Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis

21 January 2018

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DLC1 negatively regulates angiogenesis in a paracrine fashion

21 January 2018

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DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

21 January 2018

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DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

21 January 2018

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Rho GTPases in cancer cell biology

21 January 2018

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DLC1: a significant GAP in the cancer genome

21 January 2018

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Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

21 January 2018

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Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.

21 January 2018

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Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function

21 January 2018

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DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism

21 January 2018

1 reference

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The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

21 January 2018

1 reference

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Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

21 January 2018

1 reference

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p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities

21 January 2018

1 reference

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DLC1 activation requires lipid interaction through a polybasic region preceding the RhoGAP domain

21 January 2018

1 reference

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DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling

21 January 2018

1 reference

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Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

21 January 2018

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Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo

21 January 2018

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Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

21 January 2018

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The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

21 January 2018

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Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function

21 January 2018

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Rho GTPases in transformation and metastasis.

21 January 2018

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The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.

21 January 2018

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Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2

21 January 2018

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srGAP2 Arginine Methylation Regulates Cell Migration and Cell Spreading through Promoting Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

21 January 2018

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Cell migration: PKA and RhoA set the pace

21 January 2018

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Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.

21 January 2018

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Serine phosphorylation negatively regulates RhoA in vivo.

21 January 2018

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Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex

21 January 2018

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cAMP response element-binding protein is expressed at high levels in human ovarian adenocarcinoma and regulates ovarian tumor cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS2604

Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: relationship with cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Release of cAMP gating by the alpha6beta4 integrin stimulates lamellae formation and the chemotactic migration of invasive carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Cyclic AMP induces inhibition of cyclin A expression and growth arrest in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Cyclic AMP inhibition of proliferation of hepatocellular carcinoma cells is mediated by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Mutations in regulatory subunit type 1A of cyclic adenosine 5'-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS2604

Regulation of actin-based cell migration by cAMP/PKA.

21 January 2018

1 reference

12 December 2020

High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells

1 reference

12 December 2020

Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP

1 reference

12 December 2020

Deleted in liver cancer protein family in human malignancies (Review)

1 reference

12 December 2020

Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS2604

1 reference

12 May 2018

ADS bibcode

2013NatCo...4.1618K

0 references

1 reference

12 May 2018