(Q53266494)

English

Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of rapamycin in acute myeloid leukemia cells.

scientific article published on 19 February 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of rapamycin in acute myeloid leukemia cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

acute myeloid leukemia

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

author name string

Josko Mise

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Hrvoje Banfic

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Dora Visnjic

4

1 reference

Europe PubMed Central

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23 January 2020

publication date

19 February 2011

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23 January 2020

Pathology Oncology Research

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

17

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

3

1 reference

Europe PubMed Central

PubMed publication ID

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23 January 2020

645-656

1 reference

Europe PubMed Central

PubMed publication ID

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23 January 2020

https://scigraph.springernature.com/pub.10.1007/s12253-011-9365-z

0 references

Survival of acute myeloid leukemia cells requires PI3 kinase activation

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Exploiting the mammalian target of rapamycin pathway in hematologic malignancies

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

The two TORCs and Akt.

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Antileukemic activity of rapamycin in acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Acute promyelocytic leukemia: from highly fatal to highly curable

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Differentiation therapy of acute myeloid leukemia: past, present and future

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

The activity of extracellular signal-regulated kinase is required during G2/M phase before metaphase-anaphase transition in synchronized leukemia cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

LY294002 and rapamycin co-operate to inhibit T-cell proliferation

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

The PI3K inhibitor arsenal: choose your weapon!

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML.

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

The Akt-mTOR tango and its relevance to cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Phosphatidylinositol 3-kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

The Akt/mammalian target of rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation

1 reference

https://api.crossref.org/works/10.1007%2FS12253-011-9365-Z

21 January 2018

Phosphoinositide 3-kinase activity is essential for all-trans-retinoic acid-induced granulocytic differentiation of HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21336564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/21336564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21336564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone-refractory prostate cancer in a preclinical mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/21336564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21336564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPK-dependent expression of p21(WAF) and p27(kip1) in PMA-induced differentiation of HL60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21336564

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12253-011-9365-Z

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21336564%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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