(Q53290011)

13 May 2018

title

The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells (English)

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.11.002

24 August 2024

1 reference

amiodarone

15 June 2024

Anja Zahno

1

1 reference

13 May 2018

Karin Brecht

2

1 reference

13 May 2018

Réjane Morand

3

1 reference

13 May 2018

Swarna Maseneni

4

1 reference

13 May 2018

Michael Török

5

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13 May 2018

Stephan Krähenbühl

7

1 reference

13 May 2018

Peter W. Lindinger

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21070748

24 August 2024

language of work or name

English

0 references

publication date

9 November 2010

1 reference

13 May 2018

full work available at URL

https://api.elsevier.com/content/article/PII:S0006295210007999?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.11.002

https://api.elsevier.com/content/article/PII:S0006295210007999?httpAccept=text/plain

24 August 2024

1 reference

https://api.crossref.org/works/10.1016/J.BCP.2010.11.002

24 August 2024

published in

Biochemical Pharmacology

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13 May 2018

volume

81

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13 May 2018

issue

3

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13 May 2018

page(s)

432-441

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13 May 2018

cites work

Amiodarone

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Effects of amiodarone on thyroid function

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Amiodarone-induced pulmonary toxicity. Predisposing factors, clinical symptoms and treatment

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Clinical organ toxicity of antiarrhythmic compounds: ocular and pulmonary manifestations

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Histopathologic analysis of suspected amiodarone hepatotoxicity

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Amiodarone hepatotoxicity: prevalence and clinicopathologic correlations among 104 patients

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Amiodarone-induced liver toxicity

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Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II

24 August 2024

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Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice

24 August 2024

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Mechanisms of benzarone and benzbromarone-induced hepatic toxicity

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Toxicity of amiodarone and amiodarone analogues on isolated rat liver mitochondria

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Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients

24 August 2024

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Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients

24 August 2024

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Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions

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Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes

24 August 2024

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Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader

24 August 2024

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Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

24 August 2024

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An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

24 August 2024

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Advantages of in vitro cytotoxicity testing by using primary rat hepatocytes in comparison with established cell lines

24 August 2024

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Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro

24 August 2024

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The metabolic fate of amitriptyline, nortriptyline and amitriptylinoxide in man.

24 August 2024

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Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s

24 August 2024

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Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

24 August 2024

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Toxicity of statins on rat skeletal muscle mitochondria

24 August 2024

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Clinical features and management of poisoning due to antimalarial drugs

24 August 2024

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Mitochondrial bioenergetic background confers a survival advantage to HepG2 cells in response to chemotherapy.

24 August 2024

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Mitochondria and apoptosis

24 August 2024

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Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

24 August 2024

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24 August 2024

Identifiers

1 reference

13 May 2018

1 reference

13 May 2018