(Q53337896)

English

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.

scientific article published on 16 January 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation. (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

apoptotic process

0 references

Pietro Formisano

11

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

author name string

Anna Perfetti

1

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Francesco Oriente

2

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Salvatore Iovino

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

A Teresa Alberobello

4

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Alessia P M Barbagallo

5

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Iolanda Esposito

6

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Francesca Fiory

7

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Raffaele Teperino

8

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Paola Ungaro

9

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Claudia Miele

10

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Francesco Beguinot

12

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

language of work or name

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publication date

16 January 2007

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

282

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

12

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

8648-8657

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

The death effector domain protein family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

PEA-15 modulates TNFalpha intracellular signaling in astrocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

PED mediates AKT-dependent chemoresistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

RSK2 activity is regulated by its interaction with PEA-15

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

The expression of PEA-15 (phosphoprotein enriched in astrocytes of 15 kDa) defines subpopulations of astrocytes and neurons throughout the adult mouse brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Phorbol ester effects in atypical protein kinase C zeta overexpressing NIH3T3 cells: possible evidence for crosstalk between protein kinase C isoforms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Inhibition of CaMKII-mediated c-FLIP expression sensitizes malignant melanoma cells to TRAIL-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Protein kinase C ζ associates with death inducing signaling complex and regulates Fas ligand-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M608359200

21 January 2018

Identifiers

10.1074/JBC.M608359200

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/17227770

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