(Q53342336)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16953221%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer (English)

1 reference

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29 December 2019

1

1 reference

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29 December 2019

Giovanna Roncador

6

1 reference

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29 December 2019

Pedro P Medina

2

1 reference

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29 December 2019

Raquel Blanco

3

1 reference

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29 December 2019

Montse Sanchez-Cespedes

11

1 reference

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29 December 2019

author name string

Smit L

4

1 reference

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29 December 2019

Tang M

5

1 reference

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29 December 2019

Maestre L

7

1 reference

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29 December 2019

Conde E

8

1 reference

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29 December 2019

Lopez-Rios F

9

1 reference

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29 December 2019

Clevers HC

10

1 reference

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29 December 2019

language of work or name

English

0 references

publication date

4 September 2006

1 reference

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29 December 2019

1 reference

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29 December 2019

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16953221%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

issue

11

1 reference

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29 December 2019

page(s)

1616-1625

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209951

29 December 2019

exact match

0 references

cites work

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

1 reference

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

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MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

21 January 2018

1 reference

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

21 January 2018

1 reference

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Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

21 January 2018

1 reference

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Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling

21 January 2018

1 reference

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Identification and characterization of the tuberous sclerosis gene on chromosome 16

21 January 2018

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

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Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

1 reference

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Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations.

21 January 2018

1 reference

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Increased risk of cancer in the Peutz-Jeghers syndrome

21 January 2018

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Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

21 January 2018

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Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.

21 January 2018

1 reference

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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

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Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

21 January 2018

1 reference

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Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase

21 January 2018

1 reference

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

21 January 2018

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Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

21 January 2018

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

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Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

21 January 2018

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United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

21 January 2018

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

21 January 2018

1 reference

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

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Akt-dependent transformation: there is more to growth than just surviving

21 January 2018

1 reference

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Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

21 January 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

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The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

21 January 2018

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Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

21 January 2018

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

21 January 2018

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Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

21 January 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 January 2018

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A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

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