(Q53349561)

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The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development.

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

The application of structure-based assessment to support safety and chemistry diligence to manage genotoxic impurities in active pharmaceutical ingredients during drug development. (English)

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

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Krista L Dobo

1

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

Nigel Greene

2

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

Michelle O Cyr

3

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

Stéphane Caron

4

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

Warren W Ku

5

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

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7 February 2006

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

Regulatory Toxicology and Pharmacology

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

44

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

3

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

282-293

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Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP

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The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures

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Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 42 chemicals tested for carcinogenicity by the U.S. National Toxicology Program

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Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP.

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The use of structure-activity relationship analysis in the food contact notification program

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Mutagenicity studies of alpha, alpha'-dihalomethylbenzenes, alpha-methylbenzyl halides, and 1-chloromethylpyrene in the Ames assay.

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Mutagenicity studies of p-substituted benzyl derivatives in the Ames Salmonella plate-incorporation assay.

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Quantitative structure-based modeling applied to characterization and prediction of chemical toxicity

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Comparative mutagenicity of aliphatic epoxides in Salmonella.

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Computer systems for the prediction of toxicity: an update

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Towards the creation of an international toxicology information centre.

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7 January 2021

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

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7 January 2021

Structure-based methods for predicting mutagenicity and carcinogenicity: are we there yet?

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7 January 2021

Computer prediction of possible toxic action from chemical structure: an update on the DEREK system.

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7 January 2021

Computer Prediction of Possible Toxic Action from Chemical Structure; The DEREK System

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Occupational hazard evaluation of p-bromobenzyl bromide from tests for genotoxicity.

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Structural specificity of aromatic compounds with special reference to mutagenic activity in Salmonella typhimurium — a series of chloro- or fluoro-nitrobenzene derivatives

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7 January 2021

Structural features of nitroaromatics that determine mutagenic activity in Salmonella typhimurium

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The new chemicals process at the Environmental Protection Agency (EPA): structure-activity relationships for hazard identification and risk assessment

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7 January 2021

Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals

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7 January 2021

Identifiers

10.1016/J.YRTPH.2006.01.004

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

13 May 2018

http://europepmc.org/abstract/MED/16464524

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