(Q53414140)

English

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells.

scientific article published in November 1999

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

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author name string

S Melnyk

1

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

M Pogribna

2

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

B J Miller

3

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

A G Basnakian

4

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

I P Pogribny

5

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

S J James

6

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

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publication date

1 November 1999

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

146

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

1

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

35-44

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats.

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Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene

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Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage

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Thymidylate stress induces homologous recombination activity in mammalian cells

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Association of Marginal Folate Depletion With Increased Human Chromosomal Damage In Vivo: Demonstration by Analysis of Micronucleated Erythrocytes

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DNA methylation in folate deficiency: use of CpG methylase

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Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat

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Nutritional folate deficiency in Chinese hamster ovary cells. I. Characterization of the pleiotropic response and its modulation by nucleic acid precursors

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Folate and cancer: A review of the literature

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Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis

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Alcohol, low-methionine--low-folate diets, and risk of colon cancer in men

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Folic acid as a cancer-preventing agent

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Effects of folate deficiency and supplementation on methylnitrosourea-induced rat mammary tumors

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A simplified HPLC method for simultaneously quantifying ribonucleotides and deoxyribonucleotides in cell extracts or frozen tissues.

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Quantification of 3'OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay

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Cleavage of single- and double-stranded DNAs containing an abasic residue by Escherichia coli exonuclease III (AP endonuclease VI)

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Gene amplification in Chinese hamster DNA repair deficient mutants.

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles

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The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited

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Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

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Somatic recombination, gene amplification and cancer

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Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats.

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'Spontaneous' genetic damage in man: evaluation of interindividual variability, relationship among markers of damage, and influence of nutritional status

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Hamster cells with increased rates of DNA amplification, a new phenotype.

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Cloning and characterization of Chinese hamster p53 cDNA.

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Reduced rate of DNA replication fork movement in megaloblastic anemia

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Identifiers

10.1016/S0304-3835(99)00213-X

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/10656607

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