(Q53471474)

14 May 2018

title

The use of computers in the safety evaluation of drugs and other chemicals. (English)

1 reference

14 May 2018

author name string

C Ioannides

series ordinal

1

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14 May 2018

D F Lewis

series ordinal

2

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14 May 2018

D V Parke

series ordinal

3

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14 May 2018

publication date

1 July 1994

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14 May 2018

European Journal of Drug Metabolism and Pharmacokinetics

published in

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14 May 2018

volume

19

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14 May 2018

page(s)

225-233

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14 May 2018

issue

3

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14 May 2018

https://scigraph.springernature.com/pub.10.1007/bf03188925

exact match

0 references

cites work

Validation of a novel molecular orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the U.S. NCI/NTP.

1 reference

https://api.crossref.org/works/10.1007%2FBF03188925

Induction of cytochrome P 450 I and its influences in chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03188925

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03188925

Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03188925

Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03188925

Is aryl hydrocarbon hydroxylase activity a new prognostic indicator for breast cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03188925

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

21 January 2018

1 reference

12 December 2020

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes

1 reference

12 December 2020

The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals

1 reference

12 December 2020

A rationale for the non-mutagenicity of 2- and 3-aminobiphenyls.

1 reference

12 December 2020

Species variation in the metabolic activation of paracetamol to toxic intermediates: role of cytochromes p-450 and p-448

1 reference

12 December 2020

Correlation of placental microsomal activities with protein detected by antibodies to rabbit cytochrome P-450 isozyme 6 in preparations from humans exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans.

1 reference

12 December 2020

Molecular dimensions of the substrate binding site of cytochrome P-448

1 reference

12 December 2020

Metabolic oxidation of carcinogenic arylamines by rat, dog, and human hepatic microsomes and by purified flavin-containing and cytochrome P-450 monooxygenases

1 reference

12 December 2020

Computer modelling in predicting carcinogenicity

1 reference

12 December 2020

Human cytochromes P450: problems and prospects

1 reference

12 December 2020

C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity

1 reference

12 December 2020

Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients

1 reference

12 December 2020

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03188925

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14 May 2018

PubMed ID

7867665

1 reference

14 May 2018