(Q53471967)

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CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation.

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. (English)

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

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pulmonary hypertension

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based on heuristic

inferred from title

author name string

Na Li

1

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

De-Zai Dai

2

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

Yin Dai

3

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

publication date

12 June 2008

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

378

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Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

5

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

541-552

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

Impaired conduction of vasodilation along arterioles in connexin40-deficient mice

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0309-4

21 January 2018

Unbalanced collagenases/TIMP-1 expression and epithelial apoptosis in experimental lung fibrosis

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0309-4

21 January 2018

Multiple connexin expression in regenerating arterial endothelial gap junctions

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0309-4

21 January 2018

Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular abnormalities in mice lacking the endothelial gap junction proteins connexin37 and connexin40

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

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Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of the absolute configuration on pharmacological activity of antihypertensive and antiarrhythmic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potassium channel diversity in the pulmonary arteries and pulmonary veins: implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amiloride analogs inhibit chronic hypoxic pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dispersion of ventricular mRNA of RyR2 and SERCA2 associated with arrhythmogenesis in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical outcomes of bosentan in pulmonary arterial hypertension do not correlate with levels of TIMPs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connexin make-up of endothelial gap junctions in the rat pulmonary artery as revealed by immunoconfocal microscopy and triple-label immunogold electron microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less alpha-adrenoceptor antagonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ channels and pulmonary endothelial permeability: insights from study of intact lung and chronic pulmonary hypertension.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular matrix and pulmonary hypertension: control of vascular smooth muscle cell contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-kappaB in human osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CPU 86017, p-chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential role of histamine in airway remodeling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer or doxycycline aggravates pulmonary hypertension in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-9 in lung remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological efficacy of CPU 86017 on hypoxic pulmonary hypertension in rats: mediated by direct inhibition of calcium channels and antioxidant action, but indirect effects on the ET-1 pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of collagen metabolism changes in the pathogenesis of pulmonary hypertension in rats and its reversibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excess collagen in hypertensive pulmonary arteries decreases vascular distensibility

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous measurement of MMP9 and TIMP1 mRNA in human non small cell lung cancers by multiplex real time RT-PCR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connexin40 regulates renin production and blood pressure

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[The role of ion channels in apoptosis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CPU86017: a novel Class III antiarrhythmic agent with multiple actions at ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of K+ channels in pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrosis, matrix metalloproteinases, and inflammation in the heart of DOCA-salt hypertensive rats: role of ET(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide-induced Ca2+ mobilization in pulmonary arterial smooth muscle cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic hypoxia is associated with reduced delayed rectifier K+ current in rat pulmonary artery muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial dysfunction in pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cigarette smoke inhibits alveolar repair: a mechanism for the development of emphysema

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bosentan therapy of pulmonary arterial hypertension in connective tissue diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18548232

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-008-0309-4

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 May 2018

http://europepmc.org/abstract/MED/18548232

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