(Q53494043)

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Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.

scientific article published on 23 July 2014

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10 March 2020

Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil (English)

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10 March 2020

electrocardiography

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12

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10 March 2020

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10 March 2020

Loriano Galeotti

10

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10 March 2020

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L Johannesen

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10 March 2020

J W Mason

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10 March 2020

C Sanabria

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10 March 2020

K Waite-Labott

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10 March 2020

M Hong

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10 March 2020

P Guo

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10 March 2020

J Lin

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10 March 2020

J S Sørensen

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10 March 2020

J Florian

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10 March 2020

N Stockbridge

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10 March 2020

D G Strauss

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10 March 2020

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23 July 2014

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10 March 2020

Clinical Pharmacology & Therapeutics

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10 March 2020

96

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10 March 2020

5

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10 March 2020

549-558

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10 March 2020

Dealing with global safety issues : was the response to QT-liability of non-cardiac drugs well coordinated?

1 reference

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21 January 2018

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

1 reference

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21 January 2018

Thorough QT Studies: Questions and Quandaries

1 reference

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21 January 2018

Amiodarone-associated proarrhythmic effects. A review with special reference to torsade de pointes tachycardia

1 reference

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21 January 2018

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current

1 reference

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21 January 2018

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

1 reference

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21 January 2018

Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

New descriptors of T-wave morphology are independent of heart rate.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Spatial, temporal and wavefront direction characteristics of 12-lead T-wave morphology.

1 reference

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21 January 2018

Measurement and regulation of cardiac ventricular repolarization: from the QT interval to repolarization morphology

1 reference

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21 January 2018

Improving the assessment of heart toxicity for all new drugs through translational regulatory science.

1 reference

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21 January 2018

MICE models: superior to the HERG model in predicting Torsade de Pointes

1 reference

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21 January 2018

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care

1 reference

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21 January 2018

The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart

1 reference

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21 January 2018

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

The electrophysiologic effects of quinidine in the transplanted human heart

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

On the relationship between block of the cardiac Na⁺ channel and drug-induced prolongation of the QRS complex

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Differentiating electrophysiological effects and cardiac safety of drugs based on the electrocardiogram: a blinded validation

1 reference

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21 January 2018

Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Drug induced QT prolongation and torsades de pointes

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Electrical heterogeneity within the ventricular wall

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Does Tpeak-Tend provide an index of transmural dispersion of repolarization?

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

T(peak)T(end) interval in long QT syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Inhibition of late sodium current by mexiletine: a novel pharmotherapeutical approach in timothy syndrome

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Automatic extraction of ECG strips from continuous 12-lead holter recordings for QT analysis at prescheduled versus optimized time points.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

The IQ-CSRC prospective clinical Phase 1 study: "Can early QT assessment using exposure response analysis replace the thorough QT study?".

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Two automatic QT algorithms compared with manual measurement in identification of long QT syndrome

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Concentration-QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Pharmacokinetic and pharmacodynamic modeling of the effects of oral and intravenous administrations of dofetilide on ventricular repolarization*

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

21 January 2018

Drug-induced changes in the T-wave morphology

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

7 January 2021

based on heuristic

inferred from DOI database lookup

Greater quinidine-induced QTc interval prolongation in women

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

7 January 2021

based on heuristic

inferred from DOI database lookup

Influence of dofetilide on QT-interval duration and dispersion at various heart rates during exercise in humans

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

7 January 2021

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inferred from DOI database lookup

Delayed K+ current and external K+ in single cardiac Purkinje cells

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.155

7 January 2021

based on heuristic

inferred from DOI database lookup

ECG T-Wave Patterns in Genetically Distinct Forms of the Hereditary Long QT Syndrome

1 reference

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7 January 2021

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Tpeak-Tend interval as an index of global dispersion of ventricular repolarization: evaluations using monophasic action potential mapping of the epi- and endocardium in swine

1 reference

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7 January 2021

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Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes

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7 January 2021

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Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias

1 reference

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7 January 2021

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Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans

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7 January 2021

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Sex differences in the rate dependence of the T wave descending limb

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A new system of multiple-lead exercise electrocardiography

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The measurement of the Q-T interval of the electrocardiogram

1 reference

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Identifiers

10.1038/CLPT.2014.155

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25054430%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25054430%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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