(Q53556002)

15 May 2018

title

p53: a two-faced cancer gene. (English)

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15 May 2018

author name string

Michael B Kastan

series ordinal

1

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15 May 2018

Elijahu Berkovich

series ordinal

2

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15 May 2018

publication date

1 May 2007

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15 May 2018

published in

Nature Cell Biology

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15 May 2018

volume

9

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15 May 2018

page(s)

489-491

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15 May 2018

issue

5

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15 May 2018

https://scigraph.springernature.com/pub.10.1038/ncb0507-489

exact match

0 references

cites work

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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ATM: genome stability, neuronal development, and cancer cross paths

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Cell-cycle checkpoints and cancer

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Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

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Different tumor-derived p53 mutants exhibit distinct biological activities

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7 January 2021

Gain of function mutations in p53.

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7 January 2021

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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7 January 2021

Transactivation of the EGR1 gene contributes to mutant p53 gain of function

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7 January 2021

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

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7 January 2021

p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3

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7 January 2021

Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

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7 January 2021

Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

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7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

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The differential effects of mutant p53 alleles on advanced murine lung cancer

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Identifiers

DOI

10.1038/NCB0507-489

1 reference

15 May 2018

PubMed ID

17473858

1 reference

15 May 2018