(Q53567535)

15 May 2018

title

Mechanisms that prevent template inactivation by HIV-1 reverse transcriptase RNase H cleavages. (English)

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15 May 2018

author name string

Vandana Purohit

1

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15 May 2018

Bernard P Roques

2

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15 May 2018

Baek Kim

3

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15 May 2018

Robert A Bambara

4

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15 May 2018

language of work or name

English

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publication date

2 March 2007

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15 May 2018

Journal of Biological Chemistry

published in

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15 May 2018

volume

282

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15 May 2018

issue

17

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15 May 2018

page(s)

12598-12609

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15 May 2018

Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities

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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA

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Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase

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Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase

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Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H

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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

21 January 2018

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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

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Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

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Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

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Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism

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Effect of human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein on HIV-1 reverse transcriptase activity in vitro

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The effect of template RNA structure on elongation by HIV-1 reverse transcriptase.

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Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein

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Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H.

21 January 2018

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Retroviral recombination during reverse transcription

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Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination

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Mechanisms of retroviral recombination

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Human immunodeficiency virus nucleocapsid protein stimulates strand transfer from internal regions of heteropolymeric RNA templates

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Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro

21 January 2018

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Effects of donor and acceptor RNA structures on the mechanism of strand transfer by HIV-1 reverse transcriptase.

21 January 2018

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Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation

21 January 2018

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Pausing during reverse transcription increases the rate of retroviral recombination

21 January 2018

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The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region.

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Mechanistic analysis of pause site-dependent and -independent recombinogenic strand transfer from structurally diverse regions of the HIV genome.

21 January 2018

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Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis

21 January 2018

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Copy-choice recombination by reverse transcriptases: reshuffling of genetic markers mediated by RNA chaperones

21 January 2018

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Evidence that HIV-1 reverse transcriptase employs the DNA 3' end-directed primary/secondary RNase H cleavage mechanism during synthesis and strand transfer.

21 January 2018

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Effect of RNA secondary structure on RNA cleavage catalyzed by HIV-1 reverse transcriptase

21 January 2018

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Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture

21 January 2018

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The Y181C mutant of HIV-1 reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors alters the size distribution of RNase H cleavages

21 January 2018

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Truncating alpha-helix E' of p66 human immunodeficiency virus reverse transcriptase modulates RNase H function and impairs DNA strand transfer

21 January 2018

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Mutations of a conserved residue within HIV-1 ribonuclease H affect its exo- and endonuclease activities

21 January 2018

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Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.

21 January 2018

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The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

21 January 2018

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The structure of HIV-1 genomic RNA in the gp120 gene determines a recombination hot spot in vivo

21 January 2018

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Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase

21 January 2018

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Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo.

21 January 2018

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The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance

21 January 2018

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Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1.

21 January 2018

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Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M700043200

1 reference

15 May 2018

PubMed ID

17337733

1 reference

15 May 2018