(Q53594823)

16 May 2018

title

Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. (English)

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16 May 2018

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Yang Lu

1

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16 May 2018

Satoru Fukuyama

2

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16 May 2018

Ryoko Yoshida

3

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16 May 2018

Takashi Kobayashi

4

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16 May 2018

Kazuko Saeki

5

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16 May 2018

Hiroshi Shiraishi

6

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16 May 2018

Akihiko Yoshimura

7

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16 May 2018

Giichi Takaesu

8

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16 May 2018

language of work or name

English

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publication date

6 October 2006

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16 May 2018

Journal of Biological Chemistry

number of pages

8

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based on heuristic

inferred from page(s)

published in

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16 May 2018

volume

281

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16 May 2018

issue

48

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16 May 2018

page(s)

36683-36690

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16 May 2018

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

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The STATs of cancer--new molecular targets come of age

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Signal transduction of inflammatory cytokines and tumor development

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Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis

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The role of IL-6 and STAT3 in inflammation and cancer

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Independent and cooperative activation of chromosomal c-fos promoter by STAT3.

21 January 2018

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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

21 January 2018

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Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607374200

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

21 January 2018

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A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland

21 January 2018

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Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

21 January 2018

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Cloning and characterization of novel CIS family genes

21 January 2018

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Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells

21 January 2018

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Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells

21 January 2018

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A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth

21 January 2018

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Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607374200

SOCS3 negatively regulates IL-6 signaling in vivo

21 January 2018

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SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.

21 January 2018

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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

21 January 2018

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SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.

21 January 2018

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Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

21 January 2018

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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

1 reference

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M607374200

Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

21 January 2018

1 reference

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

SOCS3 regulates the plasticity of gp130 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

21 January 2018

1 reference

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Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607374200

21 January 2018

Identifiers

DOI

10.1074/JBC.M607374200

1 reference

16 May 2018

PubMed ID

17028185

1 reference

16 May 2018