(Q53613309)

16 May 2018

title

Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. (English)

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16 May 2018

author name string

Xiaoyan Zhong

series ordinal

1

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16 May 2018

Randall N Pittman

series ordinal

2

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16 May 2018

publication date

5 July 2006

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16 May 2018

published in

Human Molecular Genetics

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16 May 2018

volume

15

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16 May 2018

issue

16

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16 May 2018

page(s)

2409-2420

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16 May 2018

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

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Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

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Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

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The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation

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Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

21 January 2018

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The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

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Poly-ubiquitin Binding by the Polyglutamine Disease Protein Ataxin-3 Links Its Normal Function to Protein Surveillance Pathways

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ER-associated degradation in protein quality control and cellular regulation

21 January 2018

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Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).

21 January 2018

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For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

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Endoplasmic reticulum-associated degradation

21 January 2018

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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

21 January 2018

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Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.

21 January 2018

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A membrane protein required for dislocation of misfolded proteins from the ER

21 January 2018

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

21 January 2018

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Ubx2 links the Cdc48 complex to ER-associated protein degradation

21 January 2018

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Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

21 January 2018

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In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation

21 January 2018

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Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum

21 January 2018

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Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane

21 January 2018

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Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

21 January 2018

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Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation

21 January 2018

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

21 January 2018

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Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites

21 January 2018

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VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration

21 January 2018

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Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions

21 January 2018

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Generation of destabilized green fluorescent protein as a transcription reporter

21 January 2018

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Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

21 January 2018

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An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

21 January 2018

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

21 January 2018

1 reference

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AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation

21 January 2018

1 reference

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Retrotranslocation of MHC class I heavy chain from the endoplasmic reticulum to the cytosol is dependent on ATP supply to the ER lumen

21 January 2018

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Quality control in the endoplasmic reticulum protein factory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL164

An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.

21 January 2018

1 reference

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Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

21 January 2018

1 reference

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Ataxin-3 with an altered conformation that exposes the polyglutamine domain is associated with the nuclear matrix

21 January 2018

1 reference

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Molecular clearance of ataxin-3 is regulated by a mammalian E4

21 January 2018

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Functional division of substrate processing cofactors of the ubiquitin-selective Cdc48 chaperone

21 January 2018

1 reference

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Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

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Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system

21 January 2018

1 reference

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Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDL164

Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome

21 January 2018

1 reference

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Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

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Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDL164

1 reference

16 May 2018

PubMed ID

16822850

1 reference

16 May 2018