(Q53652323)

16 May 2018

title

The effect of age on hepatic gene transfer with self-inactivating lentiviral vectors in vivo. (English)

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16 May 2018

author name string

Frank Park

series ordinal

1

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16 May 2018

Kazuo Ohashi

series ordinal

2

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16 May 2018

Mark A Kay

series ordinal

3

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16 May 2018

publication date

1 August 2003

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16 May 2018

published in

Molecular Therapy

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16 May 2018

volume

8

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16 May 2018

issue

2

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16 May 2018

page(s)

314-323

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16 May 2018

Liver-directed gene therapy: promises, problems and prospects at the turn of the century

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Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer

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Role of hepatocyte direct hyperplasia in lentivirus-mediated liver transduction in vivo

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Modified HIV-1 based lentiviral vectors have an effect on viral transduction efficiency and gene expression in vitro and in vivo

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Efficient lentiviral transduction of liver requires cell cycling in vivo

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Production of human clotting Factor IX without toxicity in mice after vascular delivery of a lentiviral vector

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Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors

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HIV-1 genome nuclear import is mediated by a central DNA flap

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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

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7 January 2021

Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

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7 January 2021

Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

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7 January 2021

Long-term expression of human coagulation factor VIII and correction of hemophilia A after in vivo retroviral gene transfer in factor VIII-deficient mice

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Lentiviral vectors containing the human immunodeficiency virus type-1 central polypurine tract can efficiently transduce nondividing hepatocytes and antigen-presenting cells in vivo

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Lentiviral vector gene transfer into fetal rhesus monkeys (Macaca mulatta): lung-targeting approaches

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Highly efficient lentiviral vector-mediated transduction of nondividing, fully reimplantable primary hepatocytes.

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7 January 2021

Transduction of liver cells by lentiviral vectors: analysis in living animals by fluorescence imaging.

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Liver-directed gene therapy: a retroviral vector with a complete LTR and the ApoE enhancer-alpha 1-antitrypsin promoter dramatically increases expression of human alpha 1-antitrypsin in vivo

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7 January 2021

Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo

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Implication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice

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Constitutive expression of murine CTLA4Ig from a recombinant adenovirus vector results in prolonged transgene expression

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7 January 2021

Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors

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7 January 2021

Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo

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7 January 2021

A third-generation lentivirus vector with a conditional packaging system

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7 January 2021

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Identifiers

DOI

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16 May 2018

PubMed ID

12907154

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16 May 2018