(Q5383215)

English

Epiregulin

mammalian protein found in Homo sapiens

proepiregulin
EREG

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

epidermal growth factor receptor binding

determination method

3 references

24 April 2018

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

protein binding

determination method

1 reference

8 April 2019

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

growth factor activity

determination method

3 references

protein tyrosine kinase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

epidermal growth factor receptor binding

determination method

4 references

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

intracellular anatomical structure

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

extracellular space

determination method

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

extracellular space

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

clathrin-coated vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

biological process

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

negative regulation of smooth muscle cell differentiation

determination method

1 reference

8 April 2019

Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of fibroblast proliferation

determination method

1 reference

8 April 2019

Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

anatomical structure morphogenesis

determination method

1 reference

8 April 2019

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

response to peptide hormone

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

determination method

1 reference

8 April 2019

Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

mRNA transcription

determination method

1 reference

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

keratinocyte differentiation

determination method

1 reference

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of DNA replication

determination method

4 references

8 April 2019

Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

keratinocyte proliferation

determination method

1 reference

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of cell population proliferation

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

24 April 2018

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

negative regulation of epithelial cell proliferation

determination method

1 reference

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

animal organ morphogenesis

determination method

1 reference

8 April 2019

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of phosphorylation

determination method

4 references

8 April 2019

Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of cell division

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of protein kinase activity

determination method

1 reference

8 April 2019

Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

ERBB2 signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

regulation of cell motility

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

epidermal growth factor receptor signaling pathway

determination method

3 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

peptidyl-tyrosine phosphorylation

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

phosphatidylinositol phosphate biosynthetic process

determination method

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14944&geneProductId=UniProtKB:O14944

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

positive regulation of cell population proliferation

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

epidermal growth factor receptor signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

negative regulation of epidermal growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

membrane organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14944

determination method

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14944

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14944

Identifiers

MeSH descriptor ID

subject named as

Epiregulin

0 references

D12.644.276.382.562

0 references

D12.776.467.382.562

0 references

D23.529.382.562

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000244869

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000244869

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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