(Q54024197)

23 May 2018

title

Drug resistance gene transfer: Stem cell protection and therapeutic efficacy. (English)

1 reference

23 May 2018

author name string

Gerson SL

series ordinal

1

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23 May 2018

publication date

1 December 2000

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23 May 2018

published in

Experimental Hematology

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23 May 2018

volume

28

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23 May 2018

issue

12

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23 May 2018

page(s)

1315-1324

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23 May 2018

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

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Optimizing conditions for gene transfer into human hematopoietic cells

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Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1.

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Improved retroviral transduction of hematopoietic progenitors by combining methods to enhance virus-cell interaction

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Maintenance of differential methotrexate toxicity between cells expressing drug-resistant and wild-type dihydrofolate reductase activities in the presence of nucleosides through nucleoside transport inhibition

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Bicistronic and two-gene retroviral vectors for using MDR1 as a selectable marker and a therapeutic gene

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7 January 2021

Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer

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DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.

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Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy

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Retroviral-fibronectin interactions in transduction of mammalian cells

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7 January 2021

Retroviral marking and transplantation of rhesus hematopoietic cells by nonmyeloablative conditioning.

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Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture

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Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo

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No discrepancy between in vivo gene marking efficiency assessed in peripheral blood populations compared with bone marrow progenitors or CD34+ cells

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7 January 2021

FMEV vectors: both retroviral long terminal repeat and leader are important for high expression in transduced hematopoietic cells

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Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells.

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Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation.

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Competitive repopulation of retrovirally transduced haemopoietic stem cells

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Identifiers

DOI

1 reference

23 May 2018

1 reference

23 May 2018