(Q54049500)

24 May 2018

title

Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics. (English)

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24 May 2018

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2

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24 May 2018

author name string

Osterberg T

series ordinal

1

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24 May 2018

language of work or name

English

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publication date

1 January 2000

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24 May 2018

European Journal of Pharmaceutical Sciences

published in

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24 May 2018

volume

10

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24 May 2018

page(s)

295-303

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24 May 2018

issue

4

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24 May 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

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7 January 2021

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein

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Drug transfer across the blood-brain barrier and improvement of brain delivery

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7 January 2021

Transport of celiprolol across human intestinal epithelial (Caco-2) cells: mediation of secretion by multiple transporters including P-glycoprotein

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7 January 2021

Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

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7 January 2021

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics

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7 January 2021

Theoretical calculation and prediction of brain-blood partitioning of organic solutes using MolSurf parametrization and PLS statistics.

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7 January 2021

Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics

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7 January 2021

Drug-stimulated ATPase activity of the human P-glycoprotein.

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7 January 2021

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

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A general pattern for substrate recognition by P-glycoprotein.

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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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Kinetics of the multidrug transporter (P-glycoprotein) and its reversal

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Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier

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7 January 2021

10.1016/S0928-0987(00)00077-4

Identifiers

DOI

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24 May 2018

PubMed ID

10838019

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24 May 2018