(Q54104366)

24 May 2018

title

The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis. (English)

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24 May 2018

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Koo HM

1

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24 May 2018

Gray-Goodrich M

2

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24 May 2018

Kohlhagen G

3

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24 May 2018

McWilliams MJ

4

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24 May 2018

Jeffers M

5

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24 May 2018

Vaigro-Wolff A

6

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24 May 2018

Alvord WG

7

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24 May 2018

Monks A

8

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24 May 2018

Paull KD

9

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24 May 2018

Pommier Y

10

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24 May 2018

Vande Woude GF

11

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language of work or name

English

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publication date

1 February 1999

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24 May 2018

Journal of the National Cancer Institute

published in

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24 May 2018

volume

91

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24 May 2018

page(s)

236-244

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24 May 2018

issue

3

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24 May 2018

DNA topoisomerases: essential enzymes and lethal targets

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ras oncogenes: their role in neoplasia

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P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

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Hydroxyrubicin, a deaminated derivative of doxorubicin, inhibits mammalian DNA topoisomerase II and partially circumvents multidrug resistance

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Multiple Ras functions can contribute to mammalian cell transformation

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Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

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Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network

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Detection of apoptosis-associated DNA fragmentation using a rapid and quantitative filter elution assay

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DNA damage and cytotoxicity of mitoxantrone and doxorubicin in doxorubicin-sensitive and -resistant human colon carcinoma cells.

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Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

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Oncogenic transformation potentiates apoptosis, S-phase arrest and stress-kinase activation by etoposide

21 January 2018

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Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

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Apoptosis in cancer therapy: crossing the threshold

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p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

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Induction of p53-independent apoptosis associated with G2M arrest following DNA damage in human colon cancer cell lines

21 January 2018

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E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis

21 January 2018

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Metabolism of plant-derived anticancer agents

21 January 2018

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DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/JNCI/91.3.236

1 reference

24 May 2018

PubMed ID

10037101

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24 May 2018