(Q54134524)

25 May 2018

title

Selective inhibitors of the osteoclast vacuolar proton ATPase as novel bone antiresorptive agents. (English)

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25 May 2018

author name string

Farina C

series ordinal

1

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25 May 2018

Gagliardi S

series ordinal

2

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25 May 2018

publication date

1 April 1999

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25 May 2018

published in

Drug Discovery Today

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25 May 2018

volume

4

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25 May 2018

issue

4

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25 May 2018

page(s)

163-172

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25 May 2018

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border

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7 January 2021

Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts

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7 January 2021

Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency

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7 January 2021

Osteoclastic bone resorption by a polarized vacuolar proton pump

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7 January 2021

Proton channel part of vacuolar H(+)-ATPase and carbonic anhydrase II expression is stimulated in resorbing osteoclasts

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7 January 2021

Inhibition of bone resorption in vitro by antisense RNA and DNA molecules targeted against carbonic anhydrase II or two subunits of vacuolar H(+)-ATPase

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7 January 2021

Recycling receptors: The round-trip itinerary of migrant membrane proteins

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7 January 2021

The vacuolar H+-ATPase: a universal proton pump of eukaryotes

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7 January 2021

Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria

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7 January 2021

Direct observation of the rotation of F1-ATPase

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7 January 2021

Postulate for the molecular mechanism of the vacuolar H(+)-ATPase (hypothesis).

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7 January 2021

Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes

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7 January 2021

Characterization and cellular distribution of the osteoclast ruffled membrane vacuolar H+-ATPase B-subunit using isoform-specific antibodies.

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7 January 2021

Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase

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7 January 2021

Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit

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7 January 2021

The putative 116 kDa osteoclast specific vacuolar proton pump subunit has ubiquitous tissue distribution.

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7 January 2021

The ubiquitous VA68 isoform of subunit A of the vacuolar H(+)-ATPase is highly expressed in human osteoclasts

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7 January 2021

Sensitivity to nitrate and other oxyanions further distinguishes the vanadate-sensitive osteoclast proton pump from other vacuolar H(+)-ATPases

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7 January 2021

Characterization of proton transport in bone-derived membrane vesicles

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7 January 2021

A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase

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7 January 2021

Functional analysis of conserved cysteine residues in the catalytic subunit of the yeast vacuolar H(+)-ATPase.

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7 January 2021

The Kinetics of N-Ethylmaleimide Inhibition of a Vacuolar H+-ATPase and Determination of Nucleotide Dissociation Constants

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7 January 2021

Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro

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7 January 2021

Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans

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7 January 2021

Structure of a 16 kDa integral membrane protein that has identity to the putative proton channel of the vacuolar H(+)-ATPase

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7 January 2021

Interaction of organotins with a vacuolar-type H(+)-ATPase

1 reference

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7 January 2021

Interaction of dibutyltin-3-hydroxyflavone bromide with the 16 kDa proteolipid indicates the disposition of proton translocation sites of the vacuolar ATPase

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7 January 2021

Reversible inhibition of osteoclastic activity by bone-bound gallium (III)

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7 January 2021

Prodigiosin 25-C uncouples vacuolar type H(+)-ATPase, inhibits vacuolar acidification and affects glycoprotein processing

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7 January 2021

Prodigiosins as a new group of H+/Cl- symporters that uncouple proton translocators.

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7 January 2021

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.

1 reference

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7 January 2021

Inhibition of osteoclast proton transport by bafilomycin A1 abolishes bone resorption

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901321-5

7 January 2021

Destruxin B, a specific and readily reversible inhibitor of vacuolar-type H(+)-translocating ATPase

1 reference

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7 January 2021

Protein kinase C activation accelerates proton extrusion by vacuolar-type H(+)-ATPases in murine peritoneal macrophages

1 reference

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7 January 2021

The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase

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7 January 2021

Serotonin and neuroendocrine peptides influence DNA synthesis in rat and human small intestinal cells in vitro

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7 January 2021

Synthesis and structure-activity relationships of bafilomycin A1 derivatives as inhibitors of vacuolar H+-ATPase

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7 January 2021

Selective Oxidation of Hydroxy Groups of Bafilomycin A(1)

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7 January 2021

5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: novel and selective inhibitors of the vacuolar H+-ATPase of osteoclasts with bone antiresorptive activity

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7 January 2021

Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo

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7 January 2021

(2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6- pentamethylpiperidin-4-yl)-2,4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase

1 reference

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7 January 2021

Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells

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7 January 2021

Inhibitors of vacuolar-type H(+)-ATPase suppresses proliferation of cultured cells

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7 January 2021

Induction of phagocytic activity of M1 cells by an inhibitor of vacuolar H+-ATPase, bafilomycin A1.

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7 January 2021

Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH

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7 January 2021

Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1.

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7 January 2021

Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901321-5

7 January 2021

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901321-5

7 January 2021

10.1016/S1359-6446(99)01321-5

Identifiers

DOI

1 reference

25 May 2018

release_7l3er55b7jbezhz72xutcczska

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7l3er55b7jbezhz72xutcczska

24 November 2022

mapped directly with Wikidata item

PubMed ID

10322275

1 reference

25 May 2018