(Q54356981)

28 May 2018

title

Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. (English)

1 reference

28 May 2018

main subject

Malonyl-Coenzyme A

1 reference

ChEBI release 2020-05-28

1 reference

1 reference

4

1 reference

28 May 2018

author name string

Peng Xu

1

1 reference

28 May 2018

Sridhar Ranganathan

2

1 reference

28 May 2018

Zachary L Fowler

3

1 reference

28 May 2018

Mattheos A G Koffas

5

1 reference

28 May 2018

publication date

13 July 2011

1 reference

28 May 2018

published in

Metabolic Engineering

1 reference

28 May 2018

volume

13

1 reference

28 May 2018

issue

5

1 reference

28 May 2018

page(s)

578-587

1 reference

28 May 2018

Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Systems metabolic engineering: genome-scale models and beyond

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Probing the performance limits of the Escherichia coli metabolic network subject to gene additions or deletions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Engineering oilseeds for sustainable production of industrial and nutritional feedstocks: solving bottlenecks in fatty acid flux.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Metabolic engineering for plant natural product biosynthesis in microbes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Natural products in drug discovery and development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Overproduction of acetyl-CoA carboxylase activity increases the rate of fatty acid biosynthesis in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Further developments towards a genome-scale metabolic model of yeast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

The growing scope of applications of genome-scale metabolic reconstructions using Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13C constraints.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Application and engineering of fatty acid biosynthesis in Escherichia coli for advanced fuels and chemicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Microdiesel: Escherichia coli engineered for fuel production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Metabolic engineering for drug discovery and development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Antisense technology in molecular and cellular bioengineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

High-yield resveratrol production in engineered Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Quantitative analysis and engineering of fatty acid biosynthesis in E. coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

The effects of alternate optimal solutions in constraint-based genome-scale metabolic models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Competition between beta-ketothiolase and citrate synthase during poly(beta-hydroxybutyrate) synthesis in Methylobacterium rhodesianum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Predicting synthetic rescues in metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Investigation of the TCA cycle and the glyoxylate shunt in Escherichia coli BL21 and JM109 using (13)C-NMR/MS

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Biosynthesis of polyketides in heterologous hosts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Exploring the overproduction of amino acids using the bilevel optimization framework OptKnock

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

An optimization framework for identifying reaction activation/inhibition or elimination candidates for overproduction in microbial systems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Microbial 1-butanol production: Identification of non-native production routes and in silico engineering interventions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

OptForce: an optimization procedure for identifying all genetic manipulations leading to targeted overproductions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Metabolic networks in motion: 13C-based flux analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Metabolic flux analysis in Escherichia coli by integrating isotopic dynamic and isotopic stationary 13C labeling data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Metabolic flux analysis as a tool in metabolic engineering of plants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Analysis of optimality in natural and perturbed metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Genome-scale gene/reaction essentiality and synthetic lethality analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Oxygen- and growth rate-dependent regulation of Escherichia coli fumarase (FumA, FumB, and FumC) activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Design of antisense RNA constructs for downregulation of the acetone formation pathway of Clostridium acetobutylicum

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Proposed mechanism of acetate accumulation in two recombinant Escherichia coli strains during high density fermentation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Biosynthesis of natural flavanones in Saccharomyces cerevisiae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2011.06.008

10.1016/J.YMBEN.2011.06.008

7 January 2021

Identifiers

DOI

1 reference

28 May 2018

1 reference

28 May 2018