(Q54399029)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24192715%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production (English)

1 reference

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29 February 2020

1

1 reference

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29 February 2020

author name string

Hans J P M Koenen

2

1 reference

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29 February 2020

Ruben L Smeets

3

1 reference

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29 February 2020

Romy Keijsers

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24192715%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Esther van Rijssen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24192715%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Andreas Koerber

6

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29 February 2020

Peter C van de Kerkhof

7

1 reference

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29 February 2020

Annemieke M H Boots

8

1 reference

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29 February 2020

Irma Joosten

9

1 reference

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29 February 2020

language of work or name

English

0 references

publication date

5 November 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24192715%20AND%20SRC:MED&resulttype=core&format=json

Journal of Investigative Dermatology

29 February 2020

published in

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29 February 2020

volume

134

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24192715%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

4

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29 February 2020

page(s)

975-983

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24192715%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/jid.2013.459

29 February 2020

exact match

0 references

cites work

Protein kinase C-theta mediates negative feedback on regulatory T cell function

1 reference

12 December 2020

Mycophenolic acid-mediated suppression of human CD4+ T cells: more than mere guanine nucleotide deprivation

1 reference

12 December 2020

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

1 reference

12 December 2020

Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

1 reference

12 December 2020

Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis

1 reference

12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

1 reference

12 December 2020

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells

1 reference

12 December 2020

CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells.

1 reference

12 December 2020

Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720.

1 reference

12 December 2020

IL-17-producing human peripheral regulatory T cells retain suppressive function

1 reference

12 December 2020

DNA methylation controls Foxp3 gene expression

1 reference

12 December 2020

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation

1 reference

12 December 2020

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

1 reference

12 December 2020

Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts

1 reference

12 December 2020

The dark side of regulatory T cells in psoriasis

1 reference

12 December 2020

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

1 reference

12 December 2020

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

1 reference

12 December 2020

Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells

1 reference

12 December 2020

Identification of IL-17-producing FOXP3+ regulatory T cells in humans.

1 reference

12 December 2020

Differential requirement of PKC-theta in the development and function of natural regulatory T cells

1 reference

12 December 2020

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

1 reference

12 December 2020

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

1 reference

12 December 2020

Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice

1 reference

12 December 2020

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

1 reference

12 December 2020

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

1 reference

12 December 2020

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype

1 reference

12 December 2020

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.

1 reference

12 December 2020

PKC-θ function at the immunological synapse: prospects for therapeutic targeting

1 reference

12 December 2020

Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo

1 reference

12 December 2020

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1

1 reference

12 December 2020

Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.

1 reference

12 December 2020

Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin

1 reference

12 December 2020