(Q54416763)

29 May 2018

title

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT. (English)

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29 May 2018

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2

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29 May 2018

Olaf Heidenreich

10

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29 May 2018

author name string

A Gessner

1

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29 May 2018

P Garrido Castro

3

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29 May 2018

L Büchler

4

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29 May 2018

A Scholz

5

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29 May 2018

T H Brümmendorf

6

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29 May 2018

N Martinez Soria

7

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29 May 2018

J Vormoor

8

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29 May 2018

J Greil

9

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29 May 2018

publication date

5 August 2010

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29 May 2018

published in

Leukemia

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29 May 2018

volume

24

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29 May 2018

issue

10

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29 May 2018

page(s)

1751-1759

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29 May 2018

https://scigraph.springernature.com/pub.10.1038/leu.2010.155

exact match

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Multiple tumor suppressor pathways negatively regulate telomerase

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Regulation of telomerase activity by interferon regulatory factors 4 and 8 in immune cells

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Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO.

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ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

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Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

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In utero origin of t(8;21) AML1-ETO translocations in childhood acute myeloid leukemia

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

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AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

21 January 2018

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Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element.

21 January 2018

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Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

21 January 2018

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Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

21 January 2018

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Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

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A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy

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The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

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Global and Hox-specific roles for the MLL1 methyltransferase

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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

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HOXA9 is required for survival in human MLL-rearranged acute leukemias

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The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7.

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The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

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ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias

21 January 2018

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SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activity

21 January 2018

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Flow cytometry and FISH to measure the average length of telomeres (flow FISH).

21 January 2018

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Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

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Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy

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Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo

21 January 2018

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The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumors.

21 January 2018

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hDOT1L links histone methylation to leukemogenesis

21 January 2018

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Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia

21 January 2018

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The molecular biology of mixed lineage leukemia

21 January 2018

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Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation

21 January 2018

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Evidence that the Pim1 kinase gene is a direct target of HOXA9

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia

21 January 2018

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Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation

21 January 2018

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Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

Gene expression profiling of pediatric acute myelogenous leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation

21 January 2018

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A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology

21 January 2018

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21 January 2018

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7 January 2021

Amplification of repeat-containing transcribed sequences (ARTS): a transcriptome fingerprinting strategy to detect functionally relevant microsatellite mutations in cancer

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7 January 2021

Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias

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7 January 2021

Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems

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https://api.crossref.org/works/10.1038%2FLEU.2010.155

7 January 2021

Identifiers

DOI

10.1038/LEU.2010.155

1 reference

29 May 2018

1 reference

29 May 2018