(Q54427862)

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STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy?

scientific article published in February 2011

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2 February 2020

STAT3 is essential for the maintenance of neurosphere-initiating tumor cells in patients with glioblastomas: a potential for targeted therapy? (English)

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2 February 2020

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Isabelle Dusanter-Fourt

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2 February 2020

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2 February 2020

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Claire Villalva

1

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2 February 2020

Severine Martin-Lannerée

2

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2 February 2020

Ulrich Cortes

3

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2 February 2020

Fatima Dkhissi

4

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2 February 2020

Michel Wager

5

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2 February 2020

Amélie Le Corf

6

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2 February 2020

Jean-Marc Tourani

7

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2 February 2020

Lucie Karayan-Tapon

10

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2 February 2020

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1 February 2011

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2 February 2020

International Journal of Cancer

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2 February 2020

128

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2 February 2020

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2 February 2020

826-838

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2 February 2020

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Malignant glioma: genetics and biology of a grave matter.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Identification of human brain tumour initiating cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Multipotent, dedifferentiated cancer stem-like cells from brain gliomas.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Prospective identification of tumorigenic breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Temozolomide preferentially depletes cancer stem cells in glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Wnt-mediated self-renewal of neural stem/progenitor cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

What does Stat3 do?

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

The STATs of cancer--new molecular targets come of age

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

IL-6 is required for glioma development in a mouse model.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

MGMT gene silencing and benefit from temozolomide in glioblastoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Defining the actual sensitivity and specificity of the neurosphere assay in stem cell biology

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Don't look: growing clonal versus nonclonal neural stem cell colonies.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Efficient tumour formation by single human melanoma cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Stat3 activation is required for the growth of U87 cell-derived tumours in mice

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Modulatory effects of polyphenols on apoptosis induction: relevance for cancer prevention

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Combined targeting of epidermal growth factor receptor, signal transducer and activator of transcription-3, and Bcl-X(L) enhances antitumor effects in squamous cell carcinoma of the head and neck.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Function of mitochondrial Stat3 in cellular respiration

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Unphosphorylated STATs go nuclear.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Requirement of serine phosphorylation for formation of STAT-promoter complexes

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias

1 reference

https://api.crossref.org/works/10.1002%2FIJC.25416

21 January 2018

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