(Q54456295)

30 May 2018

title

Synthesis in E. coli of alpha 1-antitrypsin variants of therapeutic potential for emphysema and thrombosis. (English)

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30 May 2018

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Courtney M

1

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30 May 2018

Jallat S

2

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30 May 2018

Tessier LH

3

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30 May 2018

Benavente A

4

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30 May 2018

Crystal RG

5

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30 May 2018

Lecocq JP

6

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30 May 2018

language of work or name

English

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publication date

1 January 1985

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30 May 2018

published in

Nature

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30 May 2018

volume

313

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30 May 2018

issue

5998

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30 May 2018

page(s)

149-151

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30 May 2018

Structure and variation of human alpha 1-antitrypsin

cites work

1 reference

7 January 2021

Replacement therapy of alpha 1-antitrypsin deficiency. Reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects

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7 January 2021

PULMONARY EMPHYSEMA AND ALPHA1-ANTITRYPSIN DEFICIENCY.

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7 January 2021

The role of elastases in the development of emphysema.

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7 January 2021

alpha1-antitrypsin deficiency (first of two parts).

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7 January 2021

The effect of the oxidizing agents chloramine-T and cigarette smoke on dog serum proteinase inhibitor(s)

1 reference

7 January 2021

Cigarette Smoking Induces Functional Antiprotease Deficiency in the Lower Respiratory Tract of Humans

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7 January 2021

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity

1 reference

7 January 2021

Mutation of antitrypsin to antithrombin. alpha 1-antitrypsin Pittsburgh (358 Met leads to Arg), a fatal bleeding disorder

1 reference

7 January 2021

Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin)

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7 January 2021

High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli.

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7 January 2021

Functional alpha 1-protease inhibitor in the lower respiratory tract of cigarette smokers is not decreased

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7 January 2021

The functional activity of alpha 1-proteinase inhibitor in bronchoalveolar lavage fluids from healthy human smokers and non-smokers

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7 January 2021

Active site of alpha 1-antitrypsin: homologous site in antithrombin-III

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7 January 2021

A surprising new protein superfamily containing ovalbumin, antithrombin-III, and alpha 1-proteinase inhibitor

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7 January 2021

Conformational changes accompanying the binding of antithrombin III to thrombin

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7 January 2021

Haemorrhagic complications of heparin therapy

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7 January 2021

The influence of mRNA primary and secondary structure on human IFN-γ gene expression inE. coli

1 reference

7 January 2021

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

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7 January 2021

Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA.

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7 January 2021

DNA sequencing with chain-terminating inhibitors

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7 January 2021

Identifiers

DOI

10.1038/313149A0

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30 May 2018

Dimensions Publication ID

1025548788

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30 May 2018