(Q54468633)

30 May 2018

title

Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex. (English)

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30 May 2018

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Ian N Foltz

1

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30 May 2018

Sylvia Hu

2

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30 May 2018

Chadwick King

3

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30 May 2018

Xinle Wu

4

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30 May 2018

Chaofeng Yang

5

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30 May 2018

Wei Wang

6

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30 May 2018

Jennifer Weiszmann

7

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30 May 2018

Jennitte Stevens

8

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30 May 2018

Jiyun Sunny Chen

9

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30 May 2018

Noi Nuanmanee

10

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30 May 2018

Jamila Gupte

11

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30 May 2018

Renee Komorowski

12

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30 May 2018

Laura Sekirov

13

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30 May 2018

Todd Hager

14

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30 May 2018

Taruna Arora

15

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30 May 2018

Hongfei Ge

16

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30 May 2018

Helene Baribault

17

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30 May 2018

Fen Wang

18

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30 May 2018

Jackie Sheng

19

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30 May 2018

Margaret Karow

20

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30 May 2018

Minghan Wang

21

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30 May 2018

Yongde Luo

22

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30 May 2018

Wallace McKeehan

23

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30 May 2018

Zhulun Wang

24

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30 May 2018

Murielle M Véniant

25

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30 May 2018

Yang Li

26

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30 May 2018

language of work or name

English

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publication date

1 November 2012

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30 May 2018

Science Translational Medicine

published in

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30 May 2018

volume

4

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30 May 2018

issue

162

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30 May 2018

page(s)

162ra153

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30 May 2018

Hormone-like fibroblast growth factors and metabolic regulation

cites work

1 reference

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Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

21 January 2018

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FGF-21 as a novel metabolic regulator

21 January 2018

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

21 January 2018

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Therapeutic utilities of fibroblast growth factor 19.

21 January 2018

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Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein.

21 January 2018

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Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

21 January 2018

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Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.

21 January 2018

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Receptor antibodies as novel therapeutics for diabetes

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

FGF21 N- and C-termini play different roles in receptor interaction and activation

21 January 2018

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Understanding the structure-function relationship between FGF19 and its mitogenic and metabolic activities

21 January 2018

1 reference

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Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

21 January 2018

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Fibroblast growth factor 21 corrects obesity in mice

21 January 2018

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FGF21 reloaded: challenges of a rapidly growing field

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

FGF-21/FGF-21 receptor interaction and activation is determined by betaKlotho

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

FGF21 promotes metabolic homeostasis via white adipose and leptin in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Downstream processing of monoclonal antibodies--application of platform approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3004690

10.1126/SCITRANSLMED.3004690

21 January 2018

Identifiers

DOI

1 reference

30 May 2018

PubMed ID

23197570

1 reference

30 May 2018