(Q54526478)

30 May 2018

title

Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. (English)

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30 May 2018

author name string

Charis L Johnson

1

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30 May 2018

Jodi M Peat

2

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30 May 2018

Sonia N Volante

3

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30 May 2018

Rennian Wang

4

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30 May 2018

Carolyn A McLean

5

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30 May 2018

Christopher L Pin

6

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30 May 2018

publication date

2 May 2012

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30 May 2018

published in

Journal of Pathology

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30 May 2018

volume

228

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30 May 2018

issue

3

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30 May 2018

page(s)

351-365

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30 May 2018

Pancreatic cancer: epidemiology and risk factors.

cites work

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KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin

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Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.

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MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2.

21 January 2018

1 reference

Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis.

21 January 2018

1 reference

Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice

21 January 2018

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Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract

21 January 2018

1 reference

Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1

21 January 2018

1 reference

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

21 January 2018

1 reference

Scaling factors: transcription factors regulating subcellular domains

21 January 2018

1 reference

Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia

21 January 2018

1 reference

Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia

21 January 2018

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Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice

21 January 2018

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Dexamethasone treatment induces the reprogramming of pancreatic acinar cells to hepatocytes and ductal cells.

21 January 2018

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21 January 2018

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Regulation of zymogen granule exocytosis by Ca2+, cAMP, and PKC in pancreatic acinar cells

21 January 2018

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Regulation of CCK-induced amylase release by PKC-delta in rat pancreatic acinar cells

21 January 2018

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PKC Delta (PKCdelta) promotes tumoral progression of human ductal pancreatic cancer

21 January 2018

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A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death

21 January 2018

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Rottlerin, a novel protein kinase inhibitor

21 January 2018

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Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia

21 January 2018

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RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation

21 January 2018

1 reference

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.

21 January 2018

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Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.

21 January 2018

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Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.

21 January 2018

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Development of feeder-free culture systems for generation of ckit+sca1+ progenitors from mouse iPS cells

21 January 2018

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Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas

21 January 2018

1 reference

Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration

21 January 2018

1 reference

The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.

21 January 2018

1 reference

Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells

21 January 2018

1 reference

A novel mouse PKCδ splice variant, PKCδIX, inhibits etoposide-induced apoptosis

21 January 2018

1 reference

PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1.

21 January 2018

1 reference

Tyrosine phosphorylation regulates nuclear translocation of PKCdelta

21 January 2018

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Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence

21 January 2018

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The absence of MIST1 leads to increased ethanol sensitivity and decreased activity of the unfolded protein response in mouse pancreatic acinar cells

21 January 2018

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The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4015

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30 May 2018

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30 May 2018