(Q54533459)

31 May 2018

title

The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival. (English)

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31 May 2018

author name string

J Ursini-Siegel

1

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31 May 2018

W R Hardy

2

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31 May 2018

Y Zheng

3

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31 May 2018

C Ling

4

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31 May 2018

D Zuo

5

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31 May 2018

C Zhang

6

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31 May 2018

L Podmore

7

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31 May 2018

T Pawson

8

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31 May 2018

W J Muller

9

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31 May 2018

language of work or name

English

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publication date

30 January 2012

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31 May 2018

published in

Oncogene

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31 May 2018

volume

31

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31 May 2018

issue

48

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31 May 2018

page(s)

5038-5044

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31 May 2018

https://scigraph.springernature.com/pub.10.1038/onc.2012.4

exact match

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cites work

p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Reversibility and recurrence of IGF-IR-induced mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Mutation of a Shc binding site tyrosine residue in ErbB3/HER3 blocks heregulin-dependent activation of mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

The role of adapter protein Shc in estrogen non-genomic action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Combinatorial ShcA docking interactions support diversity in tissue morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

A novel role for 14-3-3sigma in regulating epithelial cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Unraveling breast cancer heterogeneity through transcriptomic and epigenomic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

A novel pocket in 14-3-3epsilon is required to mediate specific complex formation with cdc25C and to inhibit cell cycle progression upon activation of checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Monoclonal antibodies against polyoma virus tumor antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

The role of amino acids surrounding tyrosine 1062 in ret in specific binding of the shc phosphotyrosine-binding domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.4

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.4

1 reference

31 May 2018

Dimensions Publication ID

1011617593

0 references

Fatcat ID

release_ad56anqyfza2jklt3aks2nj72a

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ad56anqyfza2jklt3aks2nj72a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

31 May 2018