(Q54535150)

31 May 2018

title

Inactivation of Bcl-2 through IκB kinase (IKK)-dependent phosphorylation mediates apoptosis upon exposure to 4-hydroxynonenal (HNE). (English)

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31 May 2018

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Cagri Bodur

1

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31 May 2018

Ozgur Kutuk

series ordinal

2

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31 May 2018

Tugsan Tezil

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3

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31 May 2018

Huveyda Basaga

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4

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31 May 2018

publication date

1 November 2012

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31 May 2018

Journal of Cellular Physiology

published in

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31 May 2018

volume

227

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31 May 2018

issue

11

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31 May 2018

page(s)

3556-3565

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31 May 2018

Bcl-2 phosphorylation and proteasome-dependent degradation induced by paclitaxel treatment: consequences on sensitivity of isolated mitochondria to Bid.

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Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase.

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Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal

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Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

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Chlamydia pneumoniae activates IKK/I kappa B-mediated signaling, which is inhibited by 4-HNE and following primary exposure

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Image-based screening identifies novel roles for IkappaB kinase and glycogen synthase kinase 3 in axonal degeneration

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Inactivation of Bcl-2 by phosphorylation

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IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal

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The role of p38 MAPK and JNK in Arsenic trioxide-induced mitochondrial cell death in human cervical cancer cells

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Apoptosis signalling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway.

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Resveratrol protects against 4-hydroxynonenal-induced apoptosis by blocking JNK and c-JUN/AP-1 signaling.

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Three-dimensional structures of proteins involved in programmed cell death

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PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum

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TAK1 lysine 158 is required for TGF-β-induced TRAF6-mediated Smad-independent IKK/NF-κB and JNK/AP-1 activation

21 January 2018

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A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation

21 January 2018

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

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The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses

21 January 2018

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Phenotypic high-throughput screening in atherosclerosis research: focus on macrophages

21 January 2018

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Myeloperoxidase-generated oxidants and atherosclerosis

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Localization of distinct F2-isoprostanes in human atherosclerotic lesions

21 January 2018

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Oxidized low-density lipoprotein-induced apoptosis

21 January 2018

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Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression.

21 January 2018

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Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.

21 January 2018

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Involvement of c-Jun NH2-terminal kinase and nitric oxide-mediated mitochondria-dependent intrinsic pathway signaling in cardiotoxin-induced muscle cell death: role of testosterone

21 January 2018

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Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase

21 January 2018

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Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

21 January 2018

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Macrophage death and defective inflammation resolution in atherosclerosis

21 January 2018

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The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria

21 January 2018

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Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release.

21 January 2018

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 January 2018

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Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives.

21 January 2018

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Induction of tumor necrosis factor by bryostatin 1 is involved in synergistic interactions with paclitaxel in human myeloid leukemia cells

21 January 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

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BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

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Involvement of caspases in 4-hydroxy-alkenal-induced apoptosis in human leukemic cells

21 January 2018

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Bcl-2 phosphorylation is required for inhibition of oxidative stress-induced lysosomal leak and ensuing apoptosis

21 January 2018

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Bcl-2 Phosphorylation by p38 MAPK

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.24057

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31 May 2018

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31 May 2018