(Q54539826)

English

Oligonucleotides comprised of alternating 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides and D-2'-deoxyribonucleosides (2'F-ANA/DNA 'altimers') induce efficient RNA cleavage mediated by RNase H.

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

Oligonucleotides comprised of alternating 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides and D-2'-deoxyribonucleosides (2'F-ANA/DNA 'altimers') induce efficient RNA cleavage mediated by RNase H. (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

author name string

Kyung-Lyum Min

1

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

Ekaterina Viazovkina

2

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

Annie Galarneau

3

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

Michael A Parniak

4

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

Masad J Damha

5

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

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publication date

1 September 2002

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

number of pages

4

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Bioorganic & Medicinal Chemistry Letters

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

12

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

18

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

2651-2654

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Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

Role of RNase H in hybrid-arrested translation by antisense oligonucleotides

1 reference

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Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

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Gene inhibition using antisense oligodeoxynucleotides

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Toward a Broad-Based Antisense Technology

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Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

1 reference

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Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids

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Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects

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Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications

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2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies

1 reference

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Synthesis and biophysical properties of arabinonucleic acids (ANA): circular dichroic spectra, melting temperatures, and ribonuclease H susceptibility of ANA.RNA hybrid duplexes.

1 reference

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Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides

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Properties of cloned and expressed human RNase H1.

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Duplex recognition by oligonucleotides containing 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxy-2'-fluoro-D-ribose. Intermolecular 2'-OH-phosphate contacts versus sugar puckering in the stabilization of triple-helical complexes

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Sequence-dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

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The effect of two antipodal fluorine-induced sugar puckers on the conformation and stability of the Dickerson-Drew dodecamer duplex [d(CGCGAATTCGCG)]2

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NMR solution structure of an oligonucleotide hairpin with a 2'F-ANA/RNA stem: implications for RNase H specificity toward DNA/RNA hybrid duplexes

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Antisense gene inhibition by C-5-substituted deoxyuridine-containing oligodeoxynucleotides

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Identifiers

10.1016/S0960-894X(02)00439-0

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 May 2018

http://europepmc.org/abstract/MED/12182880

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