(Q54571865)

English

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells.

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

Christopher J. Burns

3

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

author name string

K A Monaghan

1

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

T Khong

2

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

A Spencer

4

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

publication date

26 July 2011

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

25

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

12

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

1891-1899

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

https://scigraph.springernature.com/pub.10.1038/leu.2011.175

0 references

A gain-of-function mutation of JAK2 in myeloproliferative disorders

1 reference

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21 January 2018

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

JAK mutations in high-risk childhood acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Janus kinases: components of multiple signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Transactivation of gp130 in myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

The bone marrow stromal microenvironment influences myeloma therapeutic response in vitro

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

CYT997 causes apoptosis in human multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Mechanism of STAT3 activation by insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

IL-6 upregulates its own receptor on some human myeloma cell lines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

In the presence of bone marrow stromal cells human multiple myeloma cells become independent of the IL-6/gp130/STAT3 pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

21 January 2018

Tyrosine phosphorylation of JAK-TYK kinases in malignant plasma cell lines growth-stimulated by interleukins 6 and 11

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

7 January 2021

based on heuristic

inferred from DOI database lookup

JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulates the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

7 January 2021

based on heuristic

inferred from DOI database lookup

CD45 expression by bone marrow plasma cells in multiple myeloma: clinical and biological correlations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.175

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/LEU.2011.175

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

1 June 2018

http://europepmc.org/abstract/MED/21788946

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