(Q54593372)

1 June 2018

title

Clotrimazole disrupts glycolysis in human breast cancer without affecting non-tumoral tissues. (English)

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6

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author name string

Raquel Guimarães Coelho

1

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Isadora de Castro Calaça

2

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Deborah de Moura Celestrini

3

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Ana Helena Correia

4

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Mauricio Augusto Silva Magalhães Costa

5

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publication date

16 April 2011

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Molecular Genetics and Metabolism

published in

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volume

103

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issue

4

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page(s)

394-398

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Detachment of glycolytic enzymes from cytoskeleton of melanoma cells induced by calmodulin antagonists

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Clotrimazole potentiates the inhibitory effects of ATP on the key glycolytic enzyme 6-phosphofructo-1-kinase

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Clotrimazole decreases human breast cancer cells viability through alterations in cytoskeleton-associated glycolytic enzymes

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Detachment of glycolytic enzymes from cytoskeleton of Lewis lung carcinoma and colon adenocarcinoma cells induced by clotrimazole and its correlation to cell viability and morphology

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The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

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Detachment of the glycolytic enzymes, phosphofructokinase and aldolase, from cytoskeleton of melanoma cells, induced by local anesthetics.

7 January 2021

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7 January 2021

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Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis

7 January 2021

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Local anesthetics induce a decrease in the levels of glucose 1, 6-bisphosphate, fructose 1,6-bisphosphate, and ATP, and in the viability of melanoma cells.

7 January 2021

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Epinephrine modulates cellular distribution of muscle phosphofructokinase.

7 January 2021

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Serotonin stimulates mouse skeletal muscle 6-phosphofructo-1-kinase through tyrosine-phosphorylation of the enzyme altering its intracellular localization

7 January 2021

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Metformin reverses hexokinase and 6-phosphofructo-1-kinase inhibition in skeletal muscle, liver and adipose tissues from streptozotocin-induced diabetic mouse

7 January 2021

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Effects of insulin and actin on phosphofructokinase activity and cellular distribution in skeletal muscle

7 January 2021

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10.1016/J.YMGME.2011.04.003

7 January 2021

Identifiers

DOI

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1 June 2018

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1 June 2018