(Q54791338)

3 June 2018

title

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab. (English)

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3 June 2018

author name string

M Pickl

series ordinal

1

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3 June 2018

C H Ries

series ordinal

2

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3 June 2018

language of work or name

English

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publication date

3 November 2008

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3 June 2018

published in

Oncogene

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3 June 2018

volume

28

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3 June 2018

issue

3

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3 June 2018

page(s)

461-468

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3 June 2018

https://scigraph.springernature.com/pub.10.1038/onc.2008.394

exact match

0 references

cites work

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Trastuzumab--mechanism of action and use in clinical practice

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p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor

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Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.

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Akt protein kinase inhibits Rac1-GTP binding through phosphorylation at serine 71 of Rac1.

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Three-dimensional culture models of normal and malignant breast epithelial cells

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Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2.

31 March 2020

1 reference

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Associations of ErbB2, beta1-integrin and lipid rafts on Herceptin (Trastuzumab) resistant and sensitive tumor cell lines.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.394

Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2.

31 March 2020

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HER2 amplification ratios by fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues

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Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

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inferred from DOI database lookup

7 January 2021

based on heuristic

Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

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Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis

31 March 2020

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Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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GM3 content modulates the EGF-activated p185c-neu levels, but not those of the constitutively activated oncoprotein p185neu

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Modeling tissue morphogenesis and cancer in 3D.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.394

The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.394

HER-2 testing in breast cancer using parallel tissue-based methods

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.394

Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.394

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.394

1 reference

3 June 2018

1 reference

3 June 2018