(Q54982736)

English

Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice.

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

author name string

S Takiguchi

1

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

E Kumazawa

2

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

T Shimazoe

3

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

A Tohgo

4

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

A Kono

5

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

publication date

1 August 1997

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

number of pages

10

1 reference

based on heuristic

inferred from page(s)

Japanese Journal of Cancer Research

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

88

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

8

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

760-769

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

A new derivative of camptothecin, irinotecan hydrochloride (cpt-11) induces programmed cell-death in leukemia-lymphoma cell-lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Comparison of topoisomerase I inhibition, DNA damage, and cytotoxicity of camptothecin derivatives presently in clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Establishment and characterization of human gastric and colonic xenograft lines resistant to CPT-11 (a new derivative of camptothecin).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Differential stabilization of eukaryotic DNA topoisomerase I cleavable complexes by camptothecin derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Intracellular carboxyl esterase activity is a determinant of cellular sensitivity to the antineoplastic agent KW-2189 in cell lines resistant to cisplatin and CPT-11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Metastatic behavior of human tumor cell lines grown in the nude mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Establishment and characterization of a human pancreatic cancer cell line (SUIT-2) producing carcinoembryonic antigen and carbohydrate antigen 19-9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Multifactorial analysis of parameters influencing chemosensitivity of human cancer xenografts in nude mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Establishment and characterization of human pancreatic cancer cell lines in tissue culture and in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Decreased expression of DNA topoisomerase I in camptothecin-resistant tumor cell lines as determined by a monoclonal antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Establishment of a camptothecin analogue (CPT-11)-resistant cell line of human non-small cell lung cancer: characterization and mechanism of resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Differential expression of DNA topoisomerase I gene between CPT-11 acquired-and native-resistant human pancreatic tumor cell lines: Detected by RNAPCR-based quantitation assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

16 June 2018

Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

13 August 2018

A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5921502

13 August 2018

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.1997.TB00448.X

21 January 2018

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.1997.TB00448.X

21 January 2018

CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 gene prevents induction of apoptosis in l1210 murine leukemia-cells by sn-38, a metabolite of the camptothecin derivative cpt-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Inhibitory effects of CPT-11 on liver metastases in nude mice injected with human pancreatic tumor cells into their spleens]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of a camptothecin derivative, CPT-11, against human tumor xenografts in nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Late phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer. CPT-11 Gastrointestinal Cancer Study Group]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase II study of CPT-11, a new derivative of camptothecin, for previously untreated non-small-cell lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of CPT-11 in patients with advanced pancreatic cancer, an EORTC early clinical trials group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[A late phase II study of CPT-11, irinotecan hydrochloride, in patients with advanced pancreatic cancer. CPT-11 Study Group on Gastrointestinal Cancer]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9330608

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1349-7006.1997.TB00448.X

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 June 2018

http://europepmc.org/abstract/PMC/5921502

ResearchGate publication ID

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