(Q55044565)

16 June 2018

title

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. (English)

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16 June 2018

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Ryan T Phan

1

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16 June 2018

Masumichi Saito

2

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16 June 2018

Yukiko Kitagawa

3

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16 June 2018

Anthony R Means

4

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16 June 2018

Riccardo Dalla-Favera

5

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16 June 2018

language of work or name

English

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publication date

9 September 2007

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16 June 2018

published in

Nature Immunology

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16 June 2018

volume

8

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16 June 2018

page(s)

1132-1139

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16 June 2018

issue

10

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16 June 2018

Clonal selection and learning in the antibody system

cites work

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Mechanisms of chromosomal translocations in B cell lymphomas

21 January 2018

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Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

21 January 2018

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The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

21 January 2018

1 reference

Control of inflammation, cytokine expression, and germinal center formation by BCL-6

21 January 2018

1 reference

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor

21 January 2018

1 reference

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression.

21 January 2018

1 reference

MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation

21 January 2018

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The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.

21 January 2018

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BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

21 January 2018

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BCL6 controls the expression of the B7-1/CD80 costimulatory receptor in germinal center B cells

21 January 2018

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Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

21 January 2018

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Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

21 January 2018

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Acetylation inactivates the transcriptional repressor BCL6.

21 January 2018

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Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.

21 January 2018

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Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas

21 January 2018

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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

21 January 2018

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BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

21 January 2018

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Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

21 January 2018

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ATM activation and DNA damage response

21 January 2018

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The ATM-mediated DNA-damage response: taking shape.

21 January 2018

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Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis

21 January 2018

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Tracking CD40 signaling during germinal center development

21 January 2018

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The DNA damage response: putting checkpoints in perspective

21 January 2018

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism

21 January 2018

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Function of WW domains as phosphoserine- or phosphothreonine-binding modules

21 January 2018

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Pin1 regulates the timing of mammalian primordial germ cell proliferation

21 January 2018

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Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes

21 January 2018

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

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Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR.

21 January 2018

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

21 January 2018

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Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics

21 January 2018

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

21 January 2018

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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

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The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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ATM gene and lymphoid malignancies

21 January 2018

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Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

21 January 2018

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Transcriptional analysis of the B cell germinal center reaction

21 January 2018

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

21 January 2018

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Mechanism of antigen-driven selection in germinal centres

21 January 2018

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21 January 2018

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7 January 2021

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

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7 January 2021

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

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7 January 2021

Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice

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7 January 2021

Identifiers

DOI

10.1038/NI1508

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16 June 2018

PubMed ID

17828269

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16 June 2018