(Q55100613)

English

Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus.

scientific article

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scholarly article

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus. (English)

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

author name string

Jeffrey M Riggs

1

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Richard N Hanna

2

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Bhargavi Rajan

3

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Kamelia Zerrouki

4

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Jodi L Karnell

5

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Divya Sagar

6

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Inna Vainshtein

7

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Erika Farmer

8

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Kimberly Rosenthal

9

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Chris Morehouse

10

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Melissa de Los Reyes

11

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Kevin Schifferli

12

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Meina Liang

13

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Miguel A Sanjuan

14

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Gary P Sims

15

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Roland Kolbeck

16

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

publication date

5 April 2018

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Lupus science & medicine

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

5

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

1

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

e000261

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

New insights into the immunopathogenesis of systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Plasmacytoid dendritic cells in autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Systemic Lupus Erythematosus: Primary Care Approach to Diagnosis and Management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

The Role of STAT Signaling Pathways in the Pathogenesis of Systemic Lupus Erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

The multifaceted biology of plasmacytoid dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

A Plasmacytoid Dendritic Cells-Type I Interferon Axis Is Critically Implicated in the Pathogenesis of Systemic Lupus Erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Targeting of type I interferon in systemic autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Advances in lupus genetics and epigenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Dose-escalation of human anti-interferon-α receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Regulation of type I interferon responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Self-priming determines high type I IFN production by plasmacytoid dendritic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

The interferon signature in autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Clinical and serological manifestations associated with interferon-α levels in childhood-onset systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Human plasmacytoid dendritic cell accumulation amplifies their type 1 interferon production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Type I interferons in systemic autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Type I interferons: crucial participants in disease amplification in autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Regulation of autoreactive B cell responses to endogenous TLR ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Structural characterization of a human Fc fragment engineered for lack of effector functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Mechanisms of type-I- and type-II-interferon-mediated signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Type I interferon correlates with serological and clinical manifestations of SLE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Immune Interferon in the Circulation of Patients with Autoimmune Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

22 June 2018

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

Systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

Systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

Interferon-alpha-inducible proteins are novel autoantigens in murine lupus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

13 August 2018

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5890856

2 November 2018

Serum interferon levels in patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacogenomics and translational simulations to bridge indications for an anti-interferon-α receptor antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/29644082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/LUPUS-2018-000261

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

1 reference

Europe PubMed Central

20 June 2018

http://europepmc.org/abstract/PMC/5890856

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