(Q5513078)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

5 references

8 April 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

identical protein binding

IPI

1 reference

8 April 2019

Biophysical and structural characterization of a folded core domain within the proregion of growth and differentiation factor-5

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

transforming growth factor beta receptor binding

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

growth factor activity

signaling receptor binding

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

regulation of apoptotic process

biological process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

negative regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

forelimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

negative regulation of mesenchymal cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

regulation of MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

SMAD protein signal transduction

2 references

27 March 2018

Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43026&geneProductId=UniProtKB:P43026

27 March 2018

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?protein=P43026&geneProductId=UniProtKB:P43026

chondrocyte differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

regulation of multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

1 reference

8 April 2019

A human chondrodysplasia due to a mutation in a TGF-beta superfamily member

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

positive regulation of pathway-restricted SMAD protein phosphorylation

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

hindlimb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

chondroblast differentiation

1 reference

8 April 2019

Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

cartilage development

1 reference

8 April 2019

negative regulation of chondrocyte differentiation

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

transmembrane receptor protein serine/threonine kinase signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

embryonic limb morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

positive regulation of chondrocyte differentiation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

positive regulation of neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

negative regulation of epithelial cell proliferation

1 reference

8 April 2019

Bone morphogenetic proteins and growth and differentiation factors in the human cornea

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

positive regulation of BMP signaling pathway

transforming growth factor beta receptor signaling pathway

1 reference

8 April 2019

Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

response to mechanical stimulus

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

ossification involved in bone remodeling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

regulation of SMAD protein signal transduction

1 reference

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

BMP signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

SMAD protein signal transduction

3 references

8 April 2019

Molecular analysis of two novel missense mutations in the GDF5 proregion that reduce protein activity and are associated with brachydactyly type C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P43026

Transforming growth factor-beta, C-terminal

Gene Atlas image

PBB GE GDF5 206614 at fs.png
732 × 530; 12 KB

0 references

has part(s)

1 reference

TGF-beta, propeptide

1 reference

Transforming growth factor beta, conserved site

1 reference

Identifiers

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference