(Q5514411)

8 references

9 May 2019

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Phosphorylation of grb10 regulates its interaction with 14-3-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Phospho-tyrosine dependent protein-protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

identical protein binding

1 reference

5 June 2018

Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

insulin receptor binding

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

plasma membrane

1 reference

9 May 2019

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

protein-containing complex

1 reference

9 May 2019

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

biological process

response to insulin

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

positive regulation of vascular endothelial growth factor receptor signaling pathway

1 reference

9 May 2019

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

insulin-like growth factor receptor signaling pathway

Ensembl genome database project

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

negative regulation of phosphorylation

Ensembl genome database project

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

positive regulation of phosphorylation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

negative regulation of glycogen biosynthetic process

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

insulin receptor signaling pathway

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13322&geneProductId=UniProtKB:Q13322

axon guidance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

1 reference

9 May 2019

negative regulation of Wnt signaling pathway

1 reference

8 April 2019

GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

negative regulation of glucose import

1 reference

9 May 2019

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

positive regulation of cold-induced thermogenesis

1 reference

9 May 2019

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

insulin receptor signaling pathway

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

negative regulation of Wnt signaling pathway

negative regulation of insulin receptor signaling pathway

Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13322

http://purl.uniprot.org/uniprot/Q13322

Gene Atlas image

PBB GE GRB10 209409 at fs.png
732 × 530; 12 KB

0 references

exact match

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers.org

Identifiers

MeSH descriptor ID

D051383

subject named as

GRB10 Adaptor Protein

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13 November 2019

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9 August 2016

language of work or name

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9 August 2016

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UMLS 2023