(Q55217577)

English

PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9023196)

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Statements

biological process

1 reference

8 July 2022

Insulin processing

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9023196

1 reference

8 July 2022

6xProinsulin:2xZn2+:1xCa2+ [secretory granule lumen]

1

object has role

1 reference

8 July 2022

1

object has role

1 reference

8 July 2022

6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen]

1

object has role

1 reference

8 July 2022

PC1:calcium cofactor [secretory granule lumen]

1

object has role

1 reference

8 July 2022

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

1 reference

8 July 2022

Direct identification of prohormone conversion site in insulin-secreting cells

1 reference

8 July 2022

Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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