(Q45317719)

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Insulin processing

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-264876)

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Statements

biological pathway

1 reference

8 July 2022

insulin processing

1 reference

8 July 2022

Peptide hormone metabolism

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-264876

1 reference

8 July 2022

Oxidation of cysteine to cystine in Proinsulin

1 reference

8 July 2022

Cystine-bonded Proinsulin translocates from the endoplasmic reticulum to the Golgi

1 reference

8 July 2022

ZnT6 transports zinc into the golgi apparatus

1 reference

8 July 2022

ZnT7 transports zinc into the golgi apparatus

1 reference

8 July 2022

Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium

1 reference

8 July 2022

Proinsulin:Zinc:Calcium complex translocates to immature secretory granule

1 reference

8 July 2022

ZnT5 transports zinc into secretory granules in pancreatic beta cells

1 reference

8 July 2022

SLC30A8 transports Zn2+ from cytosol to secretory granule

1 reference

8 July 2022

Insulin secretory granule translocates to cell cortex

1 reference

8 July 2022

Exocyst complex formation

1 reference

8 July 2022

Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))

1 reference

8 July 2022

Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)

1 reference

8 July 2022

Insulin secretory granule translocates across the cortical actin network

1 reference

8 July 2022

Insulin secretory granule docks at the plasma membrane

1 reference

8 July 2022

PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))

1 reference

8 July 2022

PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)

1 reference

8 July 2022

Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion

1 reference

8 July 2022

Insulin vesicle release: walk, kiss, pause ... then run.

1 reference

8 July 2022

Regulation of the insulin gene by glucose and fatty acids

1 reference

8 July 2022

The role of assembly in insulin's biosynthesis

1 reference

8 July 2022

Molecular determinants of regulated exocytosis

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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