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Regulation of the insulin gene by glucose and fatty acids
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
review article
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stated in
Europe PubMed Central
title
Regulation of the insulin gene by glucose and fatty acids
(English)
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
main subject
glucose
0 references
preproinsulin
1 reference
based on heuristic
inferred from title
author name string
Vincent Poitout
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
Derek Hagman
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
Roland Stein
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
Isabella Artner
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
R. Paul Robertson
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
Jamie S. Harmon
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
language of work or name
English
0 references
publication date
1 April 2006
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
published in
Journal of Nutrition
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
volume
136
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
page(s)
873–876
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stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
issue
4
1 reference
stated in
PubMed
PubMed ID
16549443
retrieved
3 February 2017
cites work
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
1 reference
stated in
PubMed Central
reference URL
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17 March 2017
Increasing triglyceride synthesis inhibits glucose-induced insulin secretion in isolated rat islets of langerhans: a study using adenoviral expression of diacylglycerol acyltransferase
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PubMed Central
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17 March 2017
Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
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PubMed Central
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17 March 2017
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
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PubMed Central
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17 March 2017
Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation
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PubMed Central
reference URL
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17 March 2017
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
1 reference
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PubMed Central
reference URL
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17 March 2017
Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence
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PubMed Central
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17 March 2017
Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
1 reference
stated in
PubMed Central
reference URL
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17 March 2017
Insulin-promoter-factor 1 is required for pancreas development in mice
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PubMed Central
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7 April 2017
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription
1 reference
stated in
PubMed Central
reference URL
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29 September 2017
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
ERK1/2-dependent activation of transcription factors required for acute and chronic effects of glucose on the insulin gene promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Regulation of gene expression by glucose in pancreatic beta -cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3'-kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
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29 September 2017
A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
29 September 2017
Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853259
retrieved
27 November 2018
Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16549443
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reduced Insulin, GLUT2, and IDX-1 in -Cells After Partial Pancreatectomy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16549443
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16549443
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16549443
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16549443
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1093/JN/136.4.873
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OpenCitations bibliographic resource ID
3814792
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3814792
PMCID
1853259
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3814792
PubMed ID
16549443
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3814792
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