(Q30436101)

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Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 June 2017

Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes (English)

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Europe PubMed Central

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21 June 2017

Jonathan Schisler

4

object named as

Jonathan C Schisler

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Europe PubMed Central

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21 June 2017

Christopher B Newgard

8

object named as

Christopher B Newgard

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Europe PubMed Central

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21 June 2017

6

object named as

Gordon C Weir

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21 June 2017

author name string

Tessy Iype

1

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Europe PubMed Central

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21 June 2017

Joshua Francis

2

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Europe PubMed Central

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21 June 2017

James C Garmey

3

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Europe PubMed Central

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21 June 2017

Rafael Nesher

5

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Europe PubMed Central

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21 June 2017

Thomas C Becker

7

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21 June 2017

Steven C Griffen

9

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21 June 2017

Raghavendra G Mirmira

10

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21 June 2017

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publication date

2 March 2005

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21 June 2017

Journal of Biological Chemistry

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21 June 2017

280

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21 June 2017

17

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21 June 2017

16798-16807

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Europe PubMed Central

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21 June 2017

Regulation of insulin gene transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Regulation of insulin gene transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Regulatory regions of rat insulin I gene necessary for expression in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Transcription factors direct the development and function of pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Identification of a novel PDX-1 binding site in the human insulin gene enhancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Insulin-promoter-factor 1 is required for pancreas development in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Experimental control of pancreatic development and maintenance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Suppression of transcription factor PDX-1/IPF1/STF-1/IDX-1 causes no decrease in insulin mRNA in MIN6 cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene Transcription in Pancreatic β Cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Regulation of insulin preRNA splicing by glucose

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Proinsulin I and II gene expression in inbred mouse strains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Regulation of Luteinizing Hormone-β and Follicle-Stimulating Hormone (FSH)-β Gene Transcription by Androgens: Testosterone Directly Stimulates FSH-β Transcription Independent from Its Role on Follistatin Gene Expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Pituitary Follistatin Gene Expression in Female Rats: Evidence That Inhibin Regulates Transcription1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Acetylation of the BETA2 transcription factor by p300-associated factor is important in insulin gene expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Three functional classes of transcriptional activation domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Transcriptional activation domains stimulate initiation and elongation at different times and via different residues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Transcriptional elongation by RNA polymerase II is stimulated by transactivators.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414381200

21 January 2018

Identifiers

10.1074/JBC.M414381200

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 June 2017

ResearchGate publication ID

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