(Q55230684)

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Interleukin-2 signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9020558)

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interleukin-2-mediated signaling pathway

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Interleukin-2 family signaling

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https://identifiers.org/reactome:R-HSA-9020558

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Interleukin-2 receptor alpha binds interleukin-2

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Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta

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Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit

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Within the IL-2R complex JAK3 phosphorylates JAK1

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JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB

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Phosphorylation of IL2RB Y338 enables SHC recruitment

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Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment

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SHC1 bound to IL2 receptor is phosphorylated

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Recruited STAT5 is phosphorylated

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Phosphorylated STAT5 is released

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STAT5 dimers translocate to the nucleus

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SYK is a substrate for JAK1

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PTK2B is phosphorylated

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JAK3 binds JAK3 inhibitors

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Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

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The biology of interleukin-2.

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Identifiers

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(Q55230684)

Interleukin-2 signaling

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