(Q55480673)

12 July 2018

title

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. (English)

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12 July 2018

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A Merlo

1

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12 July 2018

J G Herman

2

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12 July 2018

L Mao

3

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12 July 2018

D J Lee

4

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12 July 2018

E Gabrielson

5

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12 July 2018

P C Burger

6

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12 July 2018

S B Baylin

7

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12 July 2018

D Sidransky

8

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12 July 2018

language of work or name

English

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publication date

1 July 1995

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12 July 2018

published in

Nature Medicine

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12 July 2018

volume

1

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12 July 2018

page(s)

686-692

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12 July 2018

issue

7

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12 July 2018

https://scigraph.springernature.com/pub.10.1038/nm0795-686

exact match

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cites work

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Tumor suppressor genes

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Clonal expansion of p53 mutant cells is associated with brain tumour progression

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Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors

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Identification of p53 gene mutations in bladder cancers and urine samples

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Microsatellite alterations as clonal markers for the detection of human cancer

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Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia

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A cell cycle regulator potentially involved in genesis of many tumor types

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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Germline p16 mutations in familial melanoma

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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

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7 January 2021

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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7 January 2021

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

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7 January 2021

Rates of p16 (MTS1) mutations in primary tumors with 9p loss

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7 January 2021

P16 gene in uncultured tumours

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7 January 2021

Mutations and altered expression of p16INK4 in human cancer.

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7 January 2021

Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon

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7 January 2021

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

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7 January 2021

CpG-rich islands and the function of DNA methylation

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The essentials of DNA methylation

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Insights into X chromosome inactivation from studies of species variation, DNA methylation and replication, and vice versa

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Role for DNA methylation in genomic imprinting

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High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines.

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Mutation and cancer: statistical study of retinoblastoma

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The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia

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Genetic alterations during colorectal-tumor development

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"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum

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7 January 2021

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1 reference

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7 January 2021

Identifiers

DOI

10.1038/NM0795-686

1 reference

12 July 2018

Dimensions Publication ID

0 references

1 reference

12 July 2018