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The Structure and Function of Integrins
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scholarly article
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title
The Structure and Function of Integrins
(English)
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author name string
Eugene E. Marcantonio
series ordinal
1
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publication date
1996
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published in
Advances in Molecular and Cell Biology
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page(s)
1-29
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cites work
Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface
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7 January 2021
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A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing
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Amino acid sequence of the human fibronectin receptor
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Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit
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The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts
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Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains
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Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum
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Identification and function of the high affinity binding sites for Ca2+ on the surface of platelets
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Ligand-dependent and -independent integrin focal contact localization: the role of the alpha chain cytoplasmic domain.
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Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domains
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Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton
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Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly
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Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains
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Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia
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An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in an divalent cation-dependent functional complex with the disialoganglioside GD2.
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Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor
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A discrete sequence in a platelet integrin is involved in ligand recognition
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Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cells
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Growth factors from murine sarcoma virus-transformed cells
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The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
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Divalent cation regulation of the function of the leukocyte integrin LFA-1
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The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Role of the transmembrane and cytoplasmic domains in the assembly and surface exposure of the platelet integrin GPIIb/IIIa
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Regulation of alpha 2 beta 1-mediated fibroblast migration on type I collagen by shifts in the concentrations of extracellular Mg2+ and Ca2+.
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G1/S control of anchorage-independent growth in the fibroblast cell cycle
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells
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VLA proteins in the integrin family: structures, functions, and their role on leukocytes
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Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin
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Integrin modulating factor-1: a lipid that alters the function of leukocyte integrins
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site
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Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinases
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Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage
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Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Integrins: versatility, modulation, and signaling in cell adhesion
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Integrins: a family of cell surface receptors
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Multiple elevations of cytosolic-free Ca2+ in human neutrophils: initiation by adherence receptors of the integrin family
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Regulation of fibronectin receptor distribution
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.
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7 January 2021
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Transient increases in cytosolic free calcium appear to be required for the migration of adherent human neutrophils
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Attachment to fibronectin or vitronectin makes human neutrophil migration sensitive to alterations in cytosolic free calcium concentration
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Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiation
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A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
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Cell-surface regulation of beta 1-integrin activity on developing retinal neurons
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7 January 2021
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Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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An interaction between alpha-actinin and the beta 1 integrin subunit in vitro
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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Cloning and characterization of a gene that regulates cell adhesion
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Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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inferred from DOI database lookup
Multiple integrins share the ability to induce elevation of intracellular pH
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Structure/function analysis of the integrin beta 1 subunit by epitope mapping
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Cell surface distribution of fibronectin and vitronectin receptors depends on substrate composition and extracellular matrix accumulation
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Expression of normal and mutant avian integrin subunits in rodent cells
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
based on heuristic
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The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Adhesion receptors of the immune system
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7 January 2021
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The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
based on heuristic
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The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
based on heuristic
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A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin
1 reference
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https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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An alternative cytoplasmic domain of the integrin beta 3 subunit
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS1569-2558%2808%2960061-2
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7 January 2021
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10.1016/S1569-2558(08)60061-2
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