(Q56594348)

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On the mechanism of porphobilinogen deaminase. Design, synthesis, and enzymatic reactions of novel porphobilinogen analogs

article by Clotilde Pichon et al published June 1992 in Tetrahedron

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On the mechanism of porphobilinogen deaminase. Design, synthesis, and enzymatic reactions of novel porphobilinogen analogs (English)

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author name string

Clotilde Pichon

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1

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Karen R. Clemens

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2

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Alan R. Jacobson

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3

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A. Ian Scott

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publication date

June 1992

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published in

Tetrahedron

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48

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issue

23

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page(s)

4687-4712

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cites work

The biosynthesis of porphyrins, chlorophylls, and vitamin B12

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Evidence for a dipyrromethane cofactor at the catalytic site of E. coli porphobilinogen deaminase

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Biosynthesis of porphyrins and related macrocycles. Part 20. Purification of deaminase and studies on its mode of action

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Prenyltransferase. The mechanism of the reaction

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The Effect of the Carbonyl and Related Groups on the Reactivity of Halides in SN2 Reactions

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Modification of hydroxymethylbilane synthase (porphobilinogen deaminase) by pyridoxal 5'-phosphate. Demonstration of an essential lysine residue

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Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase).

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Porphobilinogen synthesis

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Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12

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Site-directed mutagenesis and high-resolution NMR spectroscopy of the active site of porphobilinogen deaminase.

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The isolation and characterization of catalytically competent porphobilinogen deaminase-intermediate complexes

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10.1016/S0040-4020(01)81567-2

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(Q56594348)

On the mechanism of porphobilinogen deaminase. Design, synthesis, and enzymatic reactions of novel porphobilinogen analogs

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