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A guide to drug discovery: The role of the medicinal chemist in drug discovery — then and now

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A guide to drug discovery: The role of the medicinal chemist in drug discovery — then and now (English)

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Joseph G. Lombardino

1

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John A. Lowe

series ordinal

2

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publication date

October 2004

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published in

Nature Reviews Drug Discovery

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volume

3

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issue

10

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page(s)

853-862

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exact match

https://scigraph.springernature.com/pub.10.1038/nrd1523

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Role of P-glycoprotein in pharmacokinetics: clinical implications

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The role of absorption, distribution, metabolism, excretion and toxicity in drug discovery

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Drug-like properties and the causes of poor solubility and poor permeability

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I(Kr): the hERG channel

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Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity

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Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

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5-HT1 and 5-HT2 binding characteristics of some quipazine analogues

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1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents

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3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.

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Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency

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Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency

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Identifiers

DOI

10.1038/NRD1523

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PubMed publication ID

15459676

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(Q56687213)

A guide to drug discovery: The role of the medicinal chemist in drug discovery — then and now

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