(Q56860338)

English

TRNT1 polymerizes CCA at the 3' end of pre-tRNA

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-6786881)

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8 July 2022

mitochondrial tRNA 3'-end processing

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8 July 2022

tRNA processing in the mitochondrion

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-6786881

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8 July 2022

5',3' cleaved pre-tRNA [mitochondrial matrix]

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8 July 2022

1

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8 July 2022

Cleaved tRNA with 3' CCA [mitochondrial matrix]

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8 July 2022

TRNA nucleotidyl transferase 1

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8 July 2022

2

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8 July 2022

diphosphate(3−) anion

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8 July 2022

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)

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8 July 2022

The 3' addition of CCA to mitochondrial tRNASer(AGY) is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1.

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8 July 2022

Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases

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8 July 2022

Decreased CCA-addition in human mitochondrial tRNAs bearing a pathogenic A4317G or A10044G mutation.

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q56860338)

TRNT1 polymerizes CCA at the 3' end of pre-tRNA

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