(Q56861007)

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Signaling by NTRK3 (TRKC)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9034015)

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neurotrophin TRK receptor signaling pathway

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https://identifiers.org/reactome:R-HSA-9034015

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Protein tyrosine phosphatases dephosphorylate NTRK3

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NTF3 activates NTRK3 signaling

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Activated NTRK3 signals through PLCG1

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Activated NTRK3 signals through RAS

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Activated NTRK3 signals through PI3K

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NTRK3 as a dependence receptor

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trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

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Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC

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Early BDNF, NT-3, and NT-4 signaling events

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Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons

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The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation

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PTPsigma binds and dephosphorylates neurotrophin receptors and can suppress NGF-dependent neurite outgrowth from sensory neurons

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Developmental co-expression and functional redundancy of tyrosine phosphatases with neurotrophin receptors in developing sensory neurons.

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Mutations in NTRK3 suggest a novel signaling pathway in human congenital heart disease

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Analysis of mitogen-activated protein kinase activation by naturally occurring splice variants of TrkC, the receptor for neurotrophin-3.

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Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis

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A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation

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ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation

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Neurotrophins: roles in neuronal development and function

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Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer.

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Identification and characterization of novel substrates of Trk receptors in developing neurons

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c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway.

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Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons.

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The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm.

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Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors.

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Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.

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The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment

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TrkC isoforms with inserts in the kinase domain show impaired signaling responses

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Identifiers

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8 July 2022

(Q56861007)

Signaling by NTRK3 (TRKC)

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